Objective To investigate the relationship between serum Angiopoietin-1 ( Ang-1 ) level and the onset, the severity and the prognosis at 90 d of acute cerebral infarction.Methods The level of serum Ang-1 was measured in 132 acute cerebral infarction patients ( case group ) and 108 healthy controls ( control group ) .The relevant clinical data was also collected.NIHSS was assessed at admission.The severity of the condition was defined according to the NIHSS score.NIHSS score <5, 5 -15 and ≥16 were defined as minor, moderate and severe condition, respectively.mRS was assessed at 90 d after admission.mRS≤2 was defined as good outcome and otherwise defined as poor outcome.Results Compared with control group, proportion of patients who had a history of smoking, hypertension, diabetes mellitus and atrial fibrillation were significant higher, serum Ang-1 concentration was significant lower ( all P<0.05 ) .Logistic analysis showed that serum Ang-1 level and a history of diabetes mellitus were associated with the occurrence of acute cerebral infarction ( all P<0.01 ) .The serum Ang-1 level in minor, moderate and severe condition patients was (1.12 ±0.35) ng/ml, (0.96 ±0.39) ng/ml and (0.76 ±0.49) ng/ml.There were significant differences among them ( P=0.003) .There was a significant relationship between the severity and the serum Ang-1 level ( r=-0.267, P=0.002 ) .Compared with good outcome patients, the poor outcome patients had significant higher NIHSS score and higher proportion of a history of hypertension, diabetes mellitus, atrial fibrillation, and lower serum Ang-1 concentration ( all P<0.05 ) .NIHSS score and serum Ang-1 concentration at admission had a significant relationship with 90 d outcome of acute cerebral infarction patients ( all P<0.01) .Conclusion Serum Ang-1 level was lower in acute cerebral infarction patients and it had significant relationship with the onset, severity and 90 d outcome of acute cerebral infaration.%目的：探讨血清血管生成素1（Ang-1）水平与急性脑梗死发病、病情严重程度及90 d预后的关系。方法对132例急性脑梗死患者（病例组）及108名健康体检者（对照组）进行血清Ang-1水平检测，同时采集相关的临床资料。病例组入院时进行NIHSS评分，将NIHSS评分＜5分者定义为病情轻度组，5～15分为病情中度组，≥16分为病情重度组。病例组90 d后随访行mRS评分，将mRS评分≤2分者定义为预后良好组，＞2分者定义为预后不良组。结果病例组吸烟史、高血压病、糖尿病、心房纤颤的比例明显高于对照组，血清Ang-1水平明显低于对照组（均P＜0.05）。 Logistic回归分析显示，糖尿病及血清Ang-1水平均与急性脑梗死的发病密切相关（均P＜0.01）。病情轻度组患者血清Ang-1水平[（1．12±0．35） ng／ml]与病情中度组[（0．96±0．39） ng／ml]、病情重度组[（0．76±0．49）ng／ml]比较，差异有统计学意义（P＝0.003）。进一步分析显示，急性脑梗死患者病情严重程度与血清Ang-1水平呈负相关（r＝－0.267，P＝0.002）。预后不良组患者的入院时NIHSS评分、高血压病、糖尿病、心房纤颤的比例均明显高于预后良好组，而血清Ang-1水平明显低于预后良好组显著降低（均P＜0.05）。 Logistic回归分析显示，入院时NIHSS评分及血清Ang-1水平均与急性脑梗死患者90 d预后密切相关（均P＜0.01）。结论急性脑梗死患者的血清Ang-1水平较低，且血清Ang-1水平与急性脑梗死的发病、病情严重程度及90 d预后均密切相关。
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