Objective To analyze the clinical features and the plasma secretory leukocyte proteinase inhibitor (SLPI) levels in children with Mycoplasma pneumoniae pneumonia (MPP). Methods Clinical data and plasma SLPI levels of 136 children with MPP were retrospectively analyzed. Results From July 2011 to June 2013,136 children (male 80, female 56) with MPP were included in the study. The onset ages of all children ranged from 11 months to 14 years (mean age, 6.2±3.0 years), and 82.4%of the cases were at the age of 4 to 14 years. One hundred and twenty six cases (92.7%) with long-last high fever, 83.8%with cough, 74.3%with rale were found in the study. Small or large patchy shadows in chest X-ray radiography were found in all the cases. At the acute phase, 72.1%with low white blood cell count, 59.6%with normal neutrophil cell and 63.2%with higher high sensitive C-reactive protein (hs-CRP) were observed. The SLPI level at the acute phase in 85 cases was (9.3±8.8) ng/ml, which was signiifcant lower than that at the convalescent phase (11.8±8.0 ng/ml, Z=3.08, P=0.002). Conclusions The clinical features of MPP are usually presented with high fever, cough, higher hs-CRP, normal or lower white blood cell and neutrophil cell count, small or large patchy shadows in chest X-ray radiography. The plasma SLPI level at the acute phase was signiifcantly lower than that in convalescent phase in children with MPP.%目的：分析肺炎支原体肺炎(MPP)患儿的临床特点及其血浆分泌型白细胞蛋白酶抑制剂(SLPI)水平的变化。方法比较分析136例MPP住院患儿的临床资料及血浆SLPI水平。结果136例MPP患儿中男80例、女56例，＞4岁占82.4%。有发热者92.7%，反复剧烈咳嗽83.8%，肺部曾闻及干湿啰音74.3%。所有患儿胸片均可见大片状或斑片状阴影。急性期白细胞计数降低72.1%，中性粒细胞百分数正常59.6%，超敏C反应蛋白(hs-CRP)增高63.2%。85例查急性期血浆SLPI水平为(9.3±8.8)ng/ml，恢复期为(11.8±8.0)ng/ml，差异有统计学意义(Z=3.08，P=0.002)。结论 MPP临床特点以发热、反复剧烈咳嗽、胸片见大片状或斑片状阴影为主，外周血白细胞计数不增高，中性粒细胞比例正常而hs-CRP增高。MPP患儿急性期血浆SLPI水平明显低于恢复期。
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