Objective:To explore the risk factors of homicide behavior in patients with schizophrenia.Method:The demographic and clinical data in 78 schizophrenics with homicide behavior (homicide group) and other 574 schizophrenics without homicide behavior (non-homicide group) were analyzed retrospectively;the risk factors of homicide in schizophrenics were analyzed by Logistic regression methods.Results:The first-onset age in homicide group was significantly higher than the non-homicide group [(28.7 ± 9.6) years old vs.(24.8 ± 7.6) years old,t =4.136,P ＜ 0.001];average education years and total disease course were lower than the non-homicide group [(7.3 ± 3.1) years vs.(9.6 ± 3.0) years,t =6.227,P =0.001;(9.0 ± 7.3) years vs.(11.2 ± 9.2) years,t =-2.049,P ＜ 0.041].The ratios of male,no partner,unemployed,rural residents,poor economic conditions,had violence behavior,not regular medication and had murdered delusion were significantly higher than those in the non-homicide group(P ＜ 0.05 or P ＜ 0.01).Logistic regression analysis showed that had violence behavior,poor economic conditions,unemployed,lived in rural areas,delusion of persecution were the risk factors of murder behavior in patients with schizophrenia;but regular medication were the protective factors.Conclusion:The characteristics of schizophrenics who had homicide behavior are older onset,shorter duration and education years.Active treatment and regular medication are necessary for schizophrenics with homicide behavior,lower income,being unemployed,rural residence or with delusion of persecution.%目的:探讨精神分裂症患者凶杀行为危险因素. 方法:回顾性分析78例有凶杀行为的精神分裂症患者(凶杀组)及同期574例无凶杀记录的精神分裂症患者(非凶杀组)的人口学及临床资料,应用Logistic回归方法对精神分裂症患者凶杀行为危险因素进行分析. 结果:凶杀组首次发病年龄明显高于非凶杀组[(28.7±9.6)岁vs (24.8±7.6)岁,t=4.136,P＜0.001],受教育年限和总病程明显低于非凶杀组[(7.3±3.1)年vs (9.6±3.0)年;t=6.227,P=0.001;(9.0±7.3)年vs(11.2±9.2)年,t=-2.049,P＜0.041];凶杀组男性、无伴侣、无业、农村居民、经济状况差、既往暴力行为、未规律服药及有被害妄想的比率明显高于非凶杀组(P ＜0.05或P＜0.01);Logistic回归分析显示既往暴力行为、经济状况差、无业、居住在农村、有被害妄想是精神分裂症患者凶杀行为的危险因素,而规律服药是保护性因素. 结论:有凶杀行为精神分裂症患者具有发病晚、病程短、教育年限低的特点;对既往有暴力行为、经济状况差、无业、居住在农村、有被害妄想的精神分裂症患者应予以积极治疗及恢复期坚持用药.
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