目的：研究哮喘患儿血清VEGF、IL－13的表达水平，探讨VEGF、IL－13在儿童哮喘发病机制中的作用。方法随机选取哮喘急性发作期患儿34例（发作期组），哮喘临床缓解患儿30例（缓解期组），正常健康体检儿童26例（对照组）。采用ELISA方法检测3组儿童血清VEGF、IL－13的水平。结果发作期组患儿血清VEGF表达水平（383．42±25．78）pg／mL明显高于缓解期组（177．95±22．46）pg／mL和对照组（70．56±18．94） pg／mL，差异有显著性意义（ P＜0．01）；缓解期组患儿血清VEGF表达水平与对照组比较，差异也具有显著性意义（ P＜0．01）。发作期组患儿血清IL－13表达水平（56．13±9．96）pg／mL明显高于缓解期组（36．72±6．29）pg／mL和对照组（20．21±2．36）pg／mL，差异有显著性意义（P＜0．01）；缓解期患儿血清IL－13表达水平与对照组比较，差异也具有显著性意义（ P＜0．01）。结论血清VEGF、IL－13表达水平升高在儿童哮喘的发病机制中起重要作用，且可反映哮喘的严重程度。%Objective To study serum VEGF and IL-13 levels in asthmatic children and explore the role of VEGF and IL-13 in pathogenesis of the disease.Methods Patients were randomly selected including 34 asthmatic children with acute exacerbation ( acute exacerbation group) , 30 asthmatic children with clinical remission ( clinical remission group) , and 26 healthy children ( control group) .Serum VEGF and IL-13 levels were measured by enzyme-linked immuno sorbent assay (ELISA).Results The levels of serum VEGF in acute exacerbation group (383.42 ±25.78) pg/mL were significantly higher than those in clinical remission group (177.95 ±22.46)pg/mL and control group (70.56 ±18.94)pg/mL (P<0.01).The levels of serum VEGF in clinical remission group were significantly higher than those in control group (P<0.01).The levels of serum IL-13 in acute exacerbation group (56.13 ±9.96)pg/mL were significantly higher than those in clinical remission group (36.72 ±6.29)pg/mL and control group (20.21 ±2.36)pg/mL (P<0.01).The levels of se-rum IL-13 in clinical remission group were significantly higher than those in control group (P<0.01).Conclusion Ele-vated serum VEGF and IL-13 may play important roles in the pathogenesis of asthma and can reflect disease severity in asthmatic children.
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