大肠癌是消化系统常见的恶性肿瘤，早期诊断、早期治疗可以改善预后。微小RNAs （ microRNAs或miR-NAs）是一类单链非编码的RNA调控因子，可作为肿瘤抑制基因或癌基因而调控肿瘤的发生、发展。近年来，随着对miRNA作用机制及其与肿瘤关系研究的深入，越来越多的证据表明，miRNA在大肠癌的表达、发生、转移、诊断、治疗、预后等方面均发挥着重要的作用。本文就近年来有关miRNA与大肠癌的关系研究进展进行综述。%Colorectal cancer is one of the most common malignant gastrointestinal tumors.Early diagnosis and prompt treatment can help to achieve a favorable prognosis.MicroRNA/miRNA, a single-strand noncoding-RNA family, func-tions as an oncogenes or tumor suppressor genes, regulating the genesis and development of tumors.Nowadays, a great a-mount of studies have been conducted on the mechanisms of microRNAs and their relationship with neoplasm.Accumulating evidences indicate that miRNAs play a vital role in tumor genesis and metastasis and serve as markers of diagnosis, treat-ment and prognosis of colorectal carcinoma.This article reviews recent studies on the relationship between miRNA and colorectal cancer.
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