目的：观察不同时间点高压氧联合山莨菪碱治疗突发性耳聋对疗效的影响。方法将166例采用高压氧治疗（ HBO）的突发性耳聋患者，分为山莨菪碱组88例与对照组78例，两组均给予常规药物治疗，山莨菪碱组每日治疗前30 min肌注山莨菪碱，比较不同时间点治疗前后听力的变化。结果在发病1天内开始治疗，山莨菪碱组38例，显效率90．48％；对照组28例，显效率80．00％；两组均可收到较好疗效；发病1天～1周内开始治疗，山莨菪碱组26例，显效率76．47％；对照组16例，显效率51．61％；山莨菪碱组比对照组效果好，差异有显著性意义（ P＜0．05）；发病2周后开始治疗，两组疗效均较差。结论高压氧联合山莨菪碱在有效时间点内治疗突发性耳聋，临床疗效肯定。%Objective To observe the effect of different time points of hyperbaric oxygen combined with anisodamine in the treatment of sudden deafness on curative effect .Methods A total of 166 patients with sudden deafness treated by hyperbaric oxygen ( HBO) were divided into anisodamine group of 88 cases and control group of 78 cases.The two groups were given routine drug treatment.In addition, the anisodamine group received intramuscular injection of anisodamine 30 minutes be-fore treatment.The changes of hearing before and after treatment were compared at different time points .Results Two groups had excellent curative effects when the treatment initiated within the first 24 hours.In anisodamine group of 38 ca-ses, the effective rate was 90.48%;in control group of 28 cases, the effective rate was 80%.Anisodamine group had bet-ter curative effects than control group within the first week , with significant difference (P<0.05).In anisodamine group of 26 cases, the effective rate was 76.47%;in control group of 16 cases, the effective rate was 51.61%.The outcome can not be improved in both groups if the treatment was initiated after 2 weeks.Conclusion Hyperbaric oxygen combined with anisodamine in the treatment of sudden deafness within the effective time has clinical curative effect affirmation .
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