Objective:To study the effect of Compound Biejiaruangan Tablets combined with entecavir therapy on liver fibrosis process and immune response state in patients with chronic hepatitis b.Methods:Patients with chronic viral hepatitis b who were treated in the Affilicated Hospital of Inner Mongolia Medical University between May 2015 and March 2017 were se-lected as the research subjects and divided into the combined group who accepted Compound Biejiaruangan Tablets combined with entecavir therapy and the control group who accepted entecavir monotherapy.The contents of collagen metabolism indexes and inflammatory response molecules in serum as well as the contents of immune cells in peripheral blood were determined be-fore treatment and 24 weeks after treatment.Results:24 weeks after treatment,PC-Ⅲ,C-Ⅳ,MMP1,MMP2,TIMP1,IL-1β,IL-18,MIF,RANTES,MIP-1α and MIP-1β contents in serum as well as Th2,Treg and Th17 contents in peripheral blood of both groups of patients were significantly lower than those before treatment whereas Th1 contents in peripheral blood were significantly higher than those before treatment(P<0.05),and PC-Ⅲ,C-Ⅳ,MMP1,MMP2,TIMP1,IL-1β,IL-18,MIF, RANTES,MIP-1α and MIP-1β contents in serum as well as Th2,Treg and Th17 contents in peripheral blood of combined group of patients were significantly lower than those of control group whereas Th1 content in peripheral blood was significantly higher than that of control group(P<0.05).Conclusion:Compound Biejiaruangan Tablets combined with entecavir therapy can delay the liver fibrosis process and improve the immune response state in patients with chronic hepatitis b.%目的:研究复方鳖甲软肝片联合恩替卡韦治疗对慢性乙肝患者肝纤维化进程及免疫应答状态的影响.方法:选择2015年5月~2017年3月在内蒙古医科大学附属医院接受治疗的慢性乙型病毒性肝炎患者作为研究对象,采用随机数表法将其分为接受复方鳖甲软肝片联合恩替卡韦治疗的联合组、接受恩替卡韦单药治疗的对照组.治疗前及治疗后24周,测定血清中胶原代谢指标、炎症反应分子的含量以及外周血中免疫细胞的含量.结果:治疗后24周时,两组患者血清PC-Ⅲ、C-Ⅳ、MMP1、MMP2、TIMP1、IL-1β、IL-18、MIF、RANTES、MIP-1α、MIP-1β的含量以及外周血中 Th2、Treg、Th17的含量均显著低于治疗前,外周血中Th1的含量显著高于治疗前(P<0.05),且联合组患者血清中PC-Ⅲ、C-Ⅳ、MMP1、MMP2、TIMP1、IL-1β、IL-18、MIF、RANTES、MIP-1α、MIP-1β的含量以及外周血中 Th2、Treg、Th17的含量均显著低于对照组,外周血中Th1的含量显著高于对照组(P<0.05).结论:复方鳖甲软肝片联合恩替卡韦治疗慢性乙肝患者能够延缓肝纤维化进程、改善免疫应答状态.
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