目的：：探讨不同肺炎支原体(MP)感染病期婴幼儿免疫功能及炎症因子水平动态及其对患儿临床治疗意义.方法：选取2014年9月~2015年5月期间住院治疗的100例肺炎支原体肺炎(MPP)患儿为观察组,依据其感染程度分为 MPP 急性期和恢复期两组,同时选取同期健康体检儿童50例为对照组,对3组婴幼儿的免疫球蛋白(IgG、IgA、IgM)及补体(C3、C4)、外周 T 淋巴细胞亚群(CD3＋、CD4＋、CD8＋)及细胞炎症因子(IL-2、IL-6、TNF-α、IL-8、IL-10、IL-13)进行检测.结果：免疫球蛋白IgG 恢复期水平明显高于急性期和对照组(P ＜0．05),急性期与恢复期 IgA 水平较对照组显著降低(P＜0．05),急性期 IgM 及补体 C3水平较对照组显著升高(P ＜0．05),在恢复期下降趋于正常,补体 C4急性期水平均显著高于恢复期,均高于对照组(P ＜0．05).MPP 急性期和恢复期的 CD3＋、CD4＋及CD4＋/CD8＋比值均明显低于对照组,且上述指标的恢复期数值显著高于急性期(P ＜0．05),CD8＋水平急性期高于恢复期,均显著高于对照组(P ＜0．05).细胞炎症因子 IL-2水平较对照组而言,急性期和恢复期水平均显著下降,且恢复期明显高于急性期(P ＜0．05),IL-6、TNF-α、IL-8、IL-10、IL-13水平检测结果急性期与恢复期水平均显著高于对照组,恢复期水平显著低于急性期(P ＜0．05).结论：婴幼儿感染 MP 后,机体的体液免疫功能和细胞免疫功能损伤,使得机体免疫系统发生紊乱,同时炎症细胞因子水平表达异常.因此,实时监测各项指标的水平动态,可明确婴幼儿的病情,提高康复率,对婴幼儿临床诊断具有一定的指导意义.%[ABSTRACT]Objective:To investigate the levels of immune function and inflammatory factors in children with mycoplas-ma pneumonia (MP)infection in different stages and its clinical significance.Methods:A total of 100 children with mycoplasma pneumoniae pneumonia (MPP)hospitalized from September 2014 to May 201 5 were selected as the observation group and di-vided into two groups of MPP acute period and recovery period on the basis of the infection degree,and 50 healthy children were selected as control group at the same time.The immunoglobulin (IgG,IgA,IgM)and complement (C3,C4),peripheral T lymphocyte subsets (CD3 + ,CD4 + ,CD8 + )and inflammatory factors (IL-2,IL-6,TNF-α,IL-8,IL-10,IL-13)of three groups of infants were detected.Results:Immunoglobulin IgG levels of recovery period were significantly higher than that in a-cute stage and the control group (P <0.05),IgA levels of acute phase and recovery phase were significantly lower than the control group (P <0.05),IgM and complement C3 levels in acute stage were significantly higher than the control group (P <0.05),during the recovery period tended to be normal,complement C4 in acute stage levels were significantly higher than those in recovery period and both higher than the control group (P <0.05).The CD3 + ,CD4 + and CD4/CD8 ratio of MPP in acute stage and recovery phase were significantly lower than the control group,and these numerical indexes of the recovery period were significantly higher than the acute stage (P <0.05),CD8 + levels in acute stage were significantly higher than that in re-covery period and both higher than control group (P <0.05).Compared with the control group,the levels of inflammatory cy-tokines IL-2 in the acute phase and recovery phase were significantly decreased,and the recovery period was significantly higher than that in acute stage (P <0.05),the test results that the levels of IL-6,TNF-α,IL-8,IL-10 and IL-13 in acute phase and recovery phase were significantly higher than those in control group and the recovery period was significantly lower than that in the acute stage (P <0.05).Conclusions:The body humoral immune function and cellular immune function damage caused by MP infection in infants and young children can lead to the disorder of immune system and the abnormal expression of inflamma-tory cytokines.Therefore,the real-time monitoring the dynamic level of the indicators can define the infants and young children's condition,improve the recovery rate,and have a certain guiding significance of the clinical diagnosis of infants and young chil-dren.
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