[ABSTRACT]Objective:To explore the application value of color Doppler ultrasound in the detection of hemodynamic change in patients with chronic kidney disease (CKD).Methods:A total of 720 patients with CKD who were admitted in our hospital were enrolled and divided into CKD2 group,CKD3 group,and CKD4 group according to K/DOQI guideline.Mean-while,100 healthy volunteers were served as the control group.The renal parenchymal thickness,length,width,thickness, and hemodynamics by the two-dimensional ultrasound and color Doppler ultrasound in the four groups were observed.Results:The renal parenchymal thickness,length,width,and thickness in CKD2 group were reduced when compared with the control group,but the difference was not statistically significant (P >0.05 );the above indicators in CKD3 group were significantly lower than those in the control group and CKD2 group (P <0.001);and the comparison of the above indicators between CKD4 group and other three groups was statistically significant (P <0.001 ).The comparison of hemodynamic parameters between CKD2 group and the control group was not statistically significant (P >0.05).The various hemodynamic parameters of Vs and Vd in CKD3 group were significantly lower than those in the control group and CKD2 group (P <0.001),while the various in-dicators of RI were significantly higher than those in the control group and CKD2 group (P <0.001).The various hemodynamic parameters of Vs and Vd in CKD4 group were significantly lower than those in the other three groups (P <0.001),while the various indicators of RI were significantly higher than those in the other three groups (P <0.001).Conclusions:Application of color Doppler ultrasound in detection of the hemodynamic change in patients with CKD can provide a reliable evidence for the disease diagnosis,condition monitoring,and prognosis evaluation,with an important application value.%目的：：探讨彩色多普勒超声在慢性肾脏病(CKD)患者血流动力学变化检查中应用的价值.方法：选取本院诊治的 CKD 患者720例为研究对象,依据 K/DOQI 指南分为 CKD2期组、CKD3期组和CKD4期组,同时选取100例健康自愿者为对照组,观察四组二维超声及彩色多普勒超声检查的肾脏实质厚度、长径、宽径、厚径及血流动力学状况.结果：肾脏宽径、长径、实质厚及厚径检查参数 CKD2期组较对照组有所下降,但差异均无统计学意义(P ＞0．05),CKD3期组显著低于对照组和 CKD2期组(P＜0．01),CKD4期组与其它各组相比各项指标参数差异均显著(P ＜0．01)；各组血流动力学参数值比较中,CKD3期组 Vs 及 Vd 各项血流动力学参数均显著低于对照组、CKD2期组,RI 中各项指标则显著高于对照组和 CKD2期(P ＜0．01),CKD4期组 Vs、Vd 各指标参数均显著低于其它各组,RI 参数均明显高于其它各组(P ＜0．01).结论：应用彩色多普勒超声检测 CKD 患者血流动力学变化能够为诊断疾病、监测病情和评估预后提供可靠依据,具有重要应用价值.
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