Objective:To investigate the influence of hyperbaric oxygen combined with psychotropic drugs on serum neu-rotransmitter and cytokine contents in patients with post-stroke depression.Methods:62 patients with post-stroke depression who were treated in the hospital between January 2015 and February 2017 were divided into routine group(n=31)and hyper-baric oxygen group(n=31)by random number table method.Routine group received antidepressant therapy,hyperbaric oxy-gen group received hyperbaric oxygen combined with antidepressant therapy,and the therapies lasted for 8 weeks.The differ-ences in the serum contents of monoamine neurotransmitters,inflammatory factors and oxidative stress indexes were compared between the two groups before and after treatment.There was no statistically significant difference in serum levels of mono-amine neurotransmitters,inflammatory factors and oxidative stress indexes between the two groups before treatment.After 8 weeks of treatment,serum monoamine neurotransmitters NE,5-HT and DA contents of hyperbaric oxygen group were higher than those of routine group;serum inflammatory factors IL-1,IL-6,IL-8 and hs-CRP contents were lower than those of rou-tine group;serum oxidative stress indexes LHP and MDA contents were lower than those of routine group whereas CAT and GSH-Px contents were higher than those of routine group.Results:Conclusions:Hyperbaric oxygen combined with psycho-tropic drug therapy can effectively increase the expression of monoamine neurotransmitters and balance the homeostasis in pa-tients with post-stroke depression.%目的:探讨高压氧联合精神类药物对脑卒中后抑郁患者血清神经递质及细胞因子含量的影响.方法:2015年1月~2017年2月间本院收治的脑卒中后抑郁患者62例,经随机数表法将入组患者分为常规组、高压氧组各31例.常规组接受抗抑郁药物治疗,高压氧组接受高压氧联合抗抑郁药物治疗,持续8周.对比两组血清中单胺类神经递质、炎症因子、氧化应激指标含量的差异.结果:治疗前,两组血清中单胺类神经递质、炎症因子、氧化应激指标含量的差异无统计学意义.治疗8周后,高压氧组血清中单胺类神经递质NE、5-HT、DA 的含量高于常规组;炎症因子IL-1、IL-6、IL-8、hs-CRP的含量低于常规组;氧化应激指标LHP、MDA的含量低于常规组,CAT、GSH-Px的含量高于常规组.结论:脑卒中后抑郁患者接受高压氧联合抗抑郁药物治疗,可有效增加单胺类神经递质表达量并均衡机体内环境稳态.
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