Objective To investigate the effect of Gab2 on the MMP synthesis of colon cancer cells. Methods Clinic in July 2015~2016 in April in our hospital accepted surgery for colon cancer patients with clinical pathology and tissue specimens, by Western blot was used to detect the joint GAB2 protein level of adaptor protein GAB2 on colon cancer cell invasion related protein of MMP-2 and MMP-9 synthesis influence. Results Cancer joint GAB2 protein positive expression with the patient' s gender, age and other clinical indicators no correlation, and is closely related to the colon cancer occurrence of distant metas-tasis, tumor size and clinical indicators, the difference is statistically significant; joint GAB2 protein positive group of MMP-9, MMP-2 level was significantly higher than that of the GAB2 negative group, the difference is statistically significant. Conclu-sion The adaptor protein Gab2 can affect the metastasis and invasion of colon cancer cells by affecting the expression of MMP-9 and MMP-2 in colon cancer cells.%目的:探讨Gab2对结肠癌细胞MMP合成的影响.方法:临床选择2015年7月~2016年4月本院收治的接受手术的结肠癌病人的临床病理资料及组织标本,应用Western blot法检测接头蛋白Gab2水平,分析接头蛋白Gab2对结肠癌细胞侵袭相关蛋白MMP-2、MMP-9合成的影响.结果:结肠癌接头蛋白Gab2的阳性表达与病人的性别、年龄等临床指标无相关性,而与结肠癌的是否发生远处转移、肿瘤直径大小等临床指标密切相关,差异有统计学意义;接头蛋白Gab2阳性组的MMP-9、MMP-2指标水平显著高于Gab2阴性组,差异有统计学意义.结论:接头蛋白Gab2可通过影响结肠癌细胞MMP-9、MMP-2的表达进而影响结肠癌细胞的转移侵袭.
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