Objective To analyze the curative effect of alprostadil combined with perindopril in the treatment of patients with proteinuria of diabetic nephropathy. Methods 94 cases of diabetic nephropathy patients were selected from July 2013 to July 2016 in our hospital, and they were randomly divided into the observation group of 47 cases and the control group with 47 cases, and the control group were treated with perindopril treatment, while the observation group were on the basis of alpros-tadil treatment. Observed the effect of two groups of patients with blood glucose, the curative effect of treatment with proteinuria, creatinine and urea nitrogen before and after treatment, and adverse reactions changed during the treatment. Results The FPG, 2h 2h-PGand HbA1c index in two groups of patients were no statistically significant difference; after treatment, FPG, 2h-PG and HbA1c of two groups of patients were significantly improved, the difference was statistically significant, but the comparison between the two groups, there was no statistically significant difference, the observation group after treatment, the total effec-tive rate was 97.87%, rate in the control group was 87.23%, and the difference was statistically significant, 24h urinary protein, blood creatinine and urea nitrogen of two groups of patients before treatment had no significant difference, two groups of pa-tients after treatment were lowed, and the 24h urinary protein, blood creatinine and urea nitrogen in observation patients after treatment, were lower than the control group. There were no serious adverse reactions in patients during the treatment period. Conclusions Alprostadil combined with perindopril in treatment of diabetic nephropathy proteinuria has curative effect, can ef-fectively improve renal function, and is suitable for clinical application.%目的:分析前列地尔联合培哚普利治疗糖尿病肾病蛋白尿的疗效,探讨其临床适用性.方法:回顾性分析从2013年7月~2016年7月于我院就诊的94例糖尿病肾病患者,简单随机分为观察组47例和对照组47例,对照组患者给予培哚普利治疗,观察组在此基础上联合前列地尔治疗.观察两组患者血糖控制情况,两组患者蛋白尿的治疗疗效,治疗前后24h尿蛋白定量,血肌酐和尿素氮等肾功指标的变化情况和用药期间的不良反应情况.结果:两组患者治疗前空腹血糖(FPG)、2h餐后血糖(2h-PG)及糖化血红蛋白(HbA1c)指标比较,差异无统计学意义;治疗后两组患者的FPG、2h-PG和HbA1c均降低,差异有统计学意义,但两组间比较,差异无统计学意义,观察组患者治疗后的总有效率为97.87%,对照组患者的总有效率为87.23%,两组患者总有效率比较,差异有统计学意义,治疗前两组患者的24h尿蛋白量,血肌酐和尿素氮之间比较无明显差异,两组患者治疗后均降低,且观察组患者治疗后24h尿蛋白量,血肌酐和尿素氮均低于对照组,两组患者治疗期间均未出现严重不良反应情况.结论:前列地尔联合培哚普利治疗糖尿病肾病蛋白尿疗效确切,可以有效改善肾功能,适合临床应用.
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