When establishing the atherosclerosis model,Chinese herbal compound was administrated to the rats.After 14 weeks,Lipids deposited on aorta basal lamina were examined by oil red,while MMP 9 and TIMP 1 were examined by immunohistochemistry.The research shows that the basal lamina of aorta was less colored by oil red in atherosclerosis rats when treatment of Chinese herbal com-pound and the positive expression of MMP 9/TIMP 1 were also inhibited.The mechanism of this ac-tion may contribute to the fact that Chinese herbal compound has good protective activity in atheroscle-rosis rats by adjusting the disorder of blood fat and depressing the expression of MMP 9/TIMP 1.%复制大鼠动脉粥样硬化(AS)模型,同时给予补肾疏肝活血通脉方预防,14周后油红染色观察动脉壁脂质沉积状况,并利用免疫组化法检测 MMP 9/TIMP 1在动脉细胞中的表达情况。结果发现,补肾疏肝活血通脉方能明显降低油红在 AS 大鼠动脉壁的着色程度,抑制 MMP 9/TIMP 1在动脉壁的阳性表达。可见,补肾疏肝活血通脉方能抑制 AS 的发生,其作用机制可能与减少脂质在体内沉积、抑制 MMP 9/TIMP 1的表达有关。
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