卵巢癌是死亡率最高的妇科恶性肿瘤,严重威胁着女性的生命健康,其发生与多种分子变化有关.表观遗传学改变与人类多种肿瘤有着密切的关系,而肿瘤抑制基因的DNA甲基化则是卵巢癌中常见的表观遗传学现象,与卵巢癌的发生、发展有着密切的联系.DNA甲基化属于基因表观遗传调控的重要方式之一.新的研究发现,DNA异常甲基化,尤其是基因启动子CpG岛高甲基化,使肿瘤抑制基因——乳腺癌易感基因1(BRCA1)、Ras相关区域1A基因(RASSF1A)等失活,在卵巢癌发生、发展中起重要作用.综述DNA异常甲基化在卵巢癌中的研究进展,可为卵巢癌发病机制、早期诊断、治疗及判断预后提供新的方法.%Ovarian cancer,the most lethal gynecological cancer,is a serious threat to women's health and lives. Various molecular changes have been identified in ovarian cancer. The change of epigenetics is closely related with the carcinogensis in human and tumor suppressor gene DNA methylation is a common phenomenon in ovarian cancer. DNA methylation is one of the main way of epigenetic mechanisms of transcription control. The new reports indicate that aberrant expression of genes result from abnormal DNA methylation of specific genes and an important effect with the carcinogenesis and development of ovarian cancer. Especially the hypermethylation of CpG island in the promoter region may contribute to the loss of tumor suppressor genes such as BRCA1 and RASSF1A so on.We summarized the research progress of DNA abnormal methylation in ovarian cancer, which would be helpful to the molecular mechanisms in early diagnosis, therapy and prognosis of ovarian cancer.
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