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首页> 中文期刊> 《吉林大学学报（医学版）》 >经皮椎体成形术联合125I放射粒子植入术治疗椎体转移瘤的效果评价

经皮椎体成形术联合125I放射粒子植入术治疗椎体转移瘤的效果评价

         
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摘要

Objective: To evaluate the clinical effect of pereutaneous vertbroplasty (PVP) combined with implantation of iodine-125 (125 I)radioactive particle in the treatment of vertebral metastasis,and to provide basis for the treatment of vertebral metastasis.Methods:A total of 69 patients with vertebral metastasis were divided into test group (n=32)and control group (n=37);the patients in test group were treated with PVP comined with implantation 125 I radioactive particle and the patients in control group were treated with PVP only.The heights of anterior and posterior vertebral bodies of the patients before and after treatment were detected by X-ray.The numerical rating scale (NRS)scores,pain relief rate and the incidence of surgical complications of the patients were recorded before operation and 1 d,1 week,1 month,3 months,and 6 months after operation.Results:The operation was successfully performed in all the patients without local bleeding;there were no movement dysfunction and nerve compression phenomenon.There was no leakage of bone cement.All the 125 I radioactive particles located well and there was no particle obscission.The heights of vertebral bodies of the patients in two groups after operation were increased compared with before operation (P <0.05).The NRS scores of the patients in two groups s at 1 d,1 week,1 month,3 months,6 months after operation were significantly decreased compared with before operation (P <0.05);compared with control group,the NRS scores of the patients in test group at 1 d,1 week, 1 month,3 months,6 months after operation were decreased (P <0.05).The incidence of pulmonary embolism or radiation myelitis complications was about 4.3% in 69 patients.Compared with control group,the difference in the incidence of complications of the patients in test group was not significant (P < 0.05 ).Conclusion:PVP combined with 125 I radioactive particle implantation is a safe and effective method in the treatment of vertebral metastasis,which can relieve the pain of the patients obviously compared with PVP.%目的:探讨经皮椎体成形术(PVP)联合125 I放射性粒子植入术治疗椎体转移瘤患者的临床疗效,为治疗椎体转移瘤提供依据.方法:69例椎体转移瘤患者分为试验组(n=32)和对照组(n=37),试验组患者采用PVP联合125 I放射性粒子植入术治疗,对照组患者单独采用PVP手术治疗.X射线片检查治疗前后患者椎体前后缘高度;观察并记录患者术前和术后1天、1周、1个月、3个月、6个月的疼痛数字评分(NRS),比较2组患者疼痛缓解率和手术并发症发生率.结果:所有患者手术过程顺利,术后未发现局部出血,未造成运动功能障碍及神经压迫现象.术后次日复查未发现骨水泥外漏现象.所有125 I放射性粒子位置良好,未见脱落.治疗后2组患者椎体高度较治疗前升高(P<0.05).与术前比较,2组患者术后1天、1周、1个月、3个月和6个月NRS评分均明显降低(P<0.05);在术后1周、1个月、3个月、6个月,试验组患者NRS评分低于对照组(P<0.05).69例患者中肺栓塞或放射性脊髓炎等手术并发症(3例)发生率为4.3%,2组患者手术并发症发生率比较差异无统计学意义(P<0.05).结论:PVP联合125 I粒子植入术治疗椎体转移瘤是一种安全有效的方法,与单独采用PVP手术治疗比较,其可以更明显地缓解患者的疼痛.

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  • 来源
    《吉林大学学报（医学版）》 |2017年第6期|1243-1247|共5页
  • 作者

    王骏臣; 胡玮; 余新林; 李月春; 郭海国; 冯智军;

  • 作者单位

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

    西北民族大学第二临床医学院介入医学与肿瘤科,甘肃 兰州 730000;

    甘肃省第二人民医院介入医学与肿瘤科,甘肃 兰州 730000;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 关节肿瘤;
  • 关键词

    经皮椎体成形术; 125I放射性粒子; 椎体转移瘤; 数字评分法;

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