目的：观察左旋氨氯地平对自发性高血压大鼠(SHR)血压和心率以及麻醉犬血压的影响。方法：经灌胃给药后用RBP-1型大鼠血压计测量SHR血压和心率；经十二指肠给药后用R M-6000型多导记录仪测量麻醉犬血压。结果：左旋氨氯地平能明显降低SHR血压和心率，能降低麻醉犬血压，与氨氯地平的作用相 近。结论：左旋氨氯地平具有确切的降压作用。%Objective:To compare the antihypertensive effect of L-amloipine with that of a mlodipine.Methods:Blood pressure and heart rate of SHRs were measured with blood press ure meter of rat (SBP-1) by administrating L-amlodipine and amlopdipine through mo uth.Hemodynamic parameter of anaesthetic dogs was determined by administrating drugs through duodenum with Polygraph System (RM6000).Results:L-amlodipine could slowly reduce the blood pressure and heart rates of clearing SHRs,it could also reduce the blood pressure of normal anaesthetic dogs and the action of L-amlodipine was similar to that of amlodipine.Conclusion:L-amlodipine as a new antihypertensive drug can significantly re duce blood pressure.
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