Study on relation among sICAM-1 level change in the patients with chronic viral hepatic disease,viral replication and the clinical significance

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Study on relation among sICAM-1 level change in the patients with chronic viral hepatic disease,viral replication and the clinical significance

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目的:探讨慢性肝病患者血清可溶性粘附分子(sICAM)水平与病毒复制及临床关系.方法:采用ELISA法对慢性肝病患者血清sICAM、炎症相关性细胞因子白细胞介素-1(IL-1)、白细胞介素-8(IL-8)及肿瘤坏死因子(TNFa)水平进行了平行测定.结果:慢性肝病患者血清sICAM-1、IL-1、IL-8及TNFα水平明显高于健康对照组;慢性乙型肝炎HBV-DNA或HBeAg阳性患者明显高于HBV-DNA或HBeAg阴性患者,且与血清总胆红素含量呈正相关.结论:sICAM-1和炎症相关性细胞因子水平与慢性肝病患者病情及携带HBV的活跃程度相关.%Objective: To observe relation among sICAM-1 level in the sera of patients with chronic viral hepatic disease, viral replication and the clinical significance. Methods: The level changes of sICAM-1, IL-1,IL-8 and TNFa in the sera of patients with chronic hepatitis B(CH),chronic severe hepatitis B(CSH) and hepatocirrhosis (HC) were detected by ELISA. Results: The levels of sICAM-1,IL-1,IL-8 and TNFa in sera of the patients with chronic viral hepatic disease were significantly higher than those of healthy control group(P<0.01). The bilirubin level in the sera of patients with chronic viral hepatic disease of different clinical types positively correlated with sICAM-1 and cytokine activities. The sICAM-1 level in the sera of HBV-DNA or HBeAg positive patients was significantly higher than those of negative patients(P<0.05,P<0.01). Conclusion: The sICAM-1 level and activities of cytokine IL-1,IL-8 and TNFa as well as the bilirubin level in the sera of the patients can reflect the necrosis degree of hepatocytes, and the sICAM-1 level and activities of IL-1,IL-8 and TNFa were related to state of HBV carrier or the active degree of HBV in patients with hepatic disease.

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《吉林大学学报（医学版）》 |2001年第4期|374-376|共3页
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Dept. of Digestive Medicine, Second Hospital, Jilin University,;

Dept. of Digestive Medicine, Second Hospital, Jilin University,;

Dept. of Digestive Medicine, Second Hospital, Jilin University,;

Dept. of Digestive Medicine, Second Hospital, Jilin University,;

Dept. of Digestive Medicine, Second Hospital, Jilin University,;

Dept. of Digestive Medicine, Second Hospital, Jilin University,;

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正文语种 chi
中图分类病毒性肝炎;人体病毒学（致病病毒）;
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Study on relation among sICAM-1 level change in the patients with chronic viral hepatic disease,viral replication and the clinical significance

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