为研究鸽源大肠杆菌的耐药性及其产超广谱β内酰胺酶(Extended Spectrum β lactamase,ESBLs)和头孢菌素酶(AmpC betalactamase,AmpC)的基因型,从临床上分离出352株鸽源大肠杆菌,通过药敏试验进行耐药性分析,再采用三维试验从以上结果中筛选出211株产 ESBLs、156株产 AmpC 的大肠杆菌进行基因型分析。结果表明：产 ESBLs 的菌株共有211株(59.94%),产 AmpC 的菌株共有156株(44.32%),其中 FOX 基因型共47株(30.13%),TEM 基因型共129株(61.14%),分别为2种酶的主要基因型。鸽源大肠杆菌对β内酰胺类、氨基糖苷类、磺胺类和四环素类等抗菌药物均有较强耐药性,表现有多重耐药性。%To investigate the drug resistance and the genotype of ESBL and AmpCβ-lactamases among Escherichia coli isolated from farm pigeons,352 strains of E .coli were isolated from pigeons in the experiment.First, antifungal susceptibility was analyzed through drug resistance,and then 21 1 strains of E .coli-producing ESBLs and 156 strains of E .coli-produ-cing AmpCβ-lactamases were screened from the above results by three-dimensional experiment and analyzed genotype.It was found that there were 21 1 (59.94%)of the E .coli which pro-duced ESBLs and 156 (44.32%)which produced AmpC.The detection rates of FOX and TEM,which were two dominant genotypes,were 47 (30.13%)and 129 (61.14%)respective-ly.The results indicates that pigeon E .coli has strong multi-drug resistance (includingβ-lactams,aminoglycosides,sulfonamides and tetracycline).
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