目的：探讨18 F－FDG PET／CT显像观察98例胸部恶性肿瘤治疗后疗效的作用。方法18 F－FDG PET／CT显像检查了98例手术＋放化疗、放化疗和氩氦刀3类治疗后的胸部恶性肿瘤患者，分析3种治疗方法的疗效；并对比同机CT病灶分布的特征，分析与18 F－FDG PET显像的异同。结果受检患者98例中阳性87例，阴性11例，其中手术＋放化疗44例（阳性34例，阴性10例）；放化疗组15例（阳性14例，阴性1例）；氩氦刀组39例（阳性39例）。各治疗组之间18 F－FDG PET／CT显示的治疗后残存病灶数量差异有显著意义（礸2＝24．40， P ＜0．001）。18 F－FDG PET显示病灶130个，病灶最大横径2．2～9．4cm，平均（5．20±1．73）cm；同机CT显示病灶132个，最大横径1．0～10．6cm，平均（4．48±2．19）cm，18 F－FDG PET与同机CT显示的病灶大小基本一致，差异无显著意义（ t ＝0．079， P ＞0．05），二者正相关性关系（ r ＝0．85， P ＜0．01）。但是PET反应的是残留恶性组织的活性而CT仅是解剖改变。18 F－FDG PET病灶的T／NT比值1．3～26．07，平均6．32±5．48。结论18 F－FDG PET／CT在观察胸部恶性肿瘤疗效中有较大临床价值。%Objective This study was performed to evaluate the ability of 18 F-FDG PET/CT to assess therapy effect for chest lesion.Methods Ninety-nine cases with chest cancer were performed using 18 F-FDG PET/CT.Those imagings were compared between 18 F-FDG PET and CT on the same instrument .Results There were Eighty-seven cases in positive and eleven cases in negative in this study.Forty-four cases (34 in positive and 10 in negative) were surgery and chemotherapy and radiotherapy treat-ment.Fifteen cases (14 in positive and 1 in negative) were treated using radio-chemotherapy methods.Thirty-nine patients were treated by argon-helium cryotherapy (positive 39 cases).There were different in residual mass among 3 groups on PET/CT (χ²=24.40, P <0.001).There were 130 and 132 lesions on PET and CT of the same instrument respectively .The diameters of le-sions were 2.2~9.4 cm(average 5.20 ±1.73 cm) on PET and 1.0~10.6 cm (average 4.48 ±2.19 cm) on CT.The mass ex-tension was not significant different ( t =0.079, P >0.05) between PET and CT.There was a positive relationship ( r =0.85, P <0.01).The target and no-target rate of mass (T/NT) were 1.3~26.07 (average 6.32 ±5.48).There were discrimination that 18 F-FDG PET showed the viability of retain malignity mass and the anatomy change on CT .Conclusion There was an impor-tant role for assessment of therapy effects with chest malignity lesions of patients using the 18 F-FDG PET/CT.
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