Objective To investigate the changes in quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) before and after the treatment of bronchi artery perfusion chemotherapy embolism (BACE) in lung cancer. Methods 18 patients who had been confirmed by pathological examination were collected, DCE-MRI was performed one day before and one month after surgery. MR images were analyzed through post-processing software to obtain four quantitative parameters, including Ktrans (volume transfer constant), Kep (the constant between tissue clearance and plasma), Ve (extracellular clearance volume fraction) and Vp (plasma volume fraction). The significant difference of pharmacokinetic parameters was detected to evaluate the BACE surgical. Results One month after the treatment, 11 patients were regarded as responders and had a significant decrease in Ktrans, Kep, and Ve (P < 0.05) while the downward trend in Vp had no statistical significance (P>0.05). The differences in Ktrans and Vp were also proven meaningful when compared responders with non-responders after treatment (P<0.05), the corresponding AUC (area under the curve), sensitivity, specificity were 1, 100％, 100％ and 0.818, 85.7％, 72.7％, respectively. Conclusion Quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging may contribute to determine the efficacy of bronchi artery perfusion chemotherapy embolism for lung cancer though large samples and long-term follow-up studies are needed.%目的 探讨动态增强磁共振成像 (DCE-MRI) 定量参数对肺癌支气管动脉灌注化疗栓塞术 (BACE) 早期疗效的评估价值.方法 收集经病理证实的18例肺癌患者, 分别于术前一天和术后1个月行DCE-MRI检查.利用后处理软件分析图像, 记录术前术后Ktrans、Kep、Ve、Vp四个定量参数的变化情况, 比较术前术后各参数的差异.结果 1个月后复查, 11例患者治疗有效, Ktrans、Kep、Ve、Vp四个数值较术前均下降, 其中Ktrans、Kep、Ve的变化有统计学意义 (P<0.05), Vp的下降无统计学意义 (P>0.05), 有效组与无效组术后四个数值相比, Ktrans和Vp的差异有统计学意义 (P<0.05), 相应的AUC (曲线下面积) 为1和0.818、灵敏度100％和85.7％, 特异度100％和72.7％.结论 DCE-MRI定量参数有助于判断肺癌BACE治疗效果, 但需要大样本、长期随访进一步研究.
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