Objective To investigate the appilication of antimicrobial drugs in general grass-root hospitals to provide scientific basis in clinic for formulating and managing interventions. Methods The retrospective investigation method was adopted to summarize and analyze the monitoring data of antimicrobial drugs use from 2007 to 2011. Results The utilization rate of antimicrobial agents during the 5 years was 75.9%(14 985/19 743) with the etiological detection rate for treatment 25.93%(1 746/6 733),of which,the utilization rate of antimicrobial agents during internal medicine departments was 62.04%(6 899/11 121) with the etiological detection rate for treatment of 24.77%(1 336/5 393);the utilization rate of antimicrobial agents in surgery systems was 93.78%(8 086/8 622),with the etiological inspection rate for treatment 30.6%(410/1 340). Among the patients, 7 452(49.73%) were given signle antimicrobial drugs,6 677(44.56%) in double and 948(6.33%) in triple. Conclusion The antimicrobial drugs management of grass-root hospitals is poor in our country,which is expected to carry out comprehensive mea-sures,enhance the management strengen and improve the rational use of antimicrobial drugs in general grass-root hospitals.%目的：分析综合性基层医院抗菌药物应用的临床特点，为制定管理干预措施提供科学依据。方法采用回顾性调查方法将2007～2011年淮安市第一人民医院一分院住院患者抗菌药物应用监测资料进行汇总和统计分析。结果5年间抗菌药物使用率为75.90%（14985/19743），治疗用病原学送检率为25.93%（1746/6733）；其中内科抗菌药物使用率为62.04%（6899/11121），治疗用病原学送检率为24.77%（1336/5393）；外科系统抗菌药物使用率为93.78%（8086/8622），治疗用病原学送检率为30.6%（410/1340）。使用抗菌药物患者中，使用单联抗菌药物7452例（49.73%），使用二联抗菌药物6677例（44.56%），使用三联抗菌药物948例（6.33%）。结论基层医院的抗菌药物管理仍然是我国抗菌药物管理的薄弱环节，需要采取综合措施，加强管理力度，促进基层医院抗菌药物的合理应用。
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