目的：探讨子宫肌瘤患者血清基质金属蛋白酶9（MMP－9）、表皮生长因子（EGF）水平变化及诊断子宫肌瘤的临床价值。方法：选取84例经病理学确诊的子宫肌瘤患者（病例组）、84例健康妇女作为对照组，分别对比两组血清MMP－9、E GF水平，并根据肌瘤生长位置、肌瘤大小对病例组进行亚组分析。结果：病例组患者的血清MMP－9、EGF水平均高于对照组，差异具有统计学意义（P＜0．05）；MMP－9鉴别诊断子宫肌瘤与健康人群的最佳临界值为1．40μg／ml，EGF鉴别诊断子宫肌瘤与健康人群的最佳临界值为288．5pg／ml，对应的ROC曲线下面积AUC值分别为0．816、0．739。黏膜下肌瘤患者的血清MMP－9、EGF水平均高于肌壁间肌瘤患者，差异具有统计学意义（P＜0．05）；肌瘤最大径＞5．0cm 和肌瘤最大径≤5．0cm患者的血清MMP－9、EGF水平差异不具有统计学意义（P＞0．05）。结论：检测血清MMP－9、EGF水平有利于鉴别诊断子宫肌瘤患者。%Objective:To investigate the changes of serum matrix metalloproteinase 9 (MMP-9 )and epidermal growth factor (EGF)levels in patients with uterine leiomyoma and the clinical value of the diagnosis of uterine myo-ma.Methods:A total of 84 cases of uterine fibroids were diagnosed by pathology (case group)and 84 healthy women as control group,compared two groups of serum MMP-9,EGF levels,and according to the position and size of myoma of leiomyoma,subgroup analysis was performed in cases group.Results:Cases of serum MMP-9 and EGF levels were higher than the control group,the difference was statistically significant (P<0.05 ).The optimal critical value of MMP-9 in differential diagnosis of uterine myoma and healthy people was 1 .40μg/ml,the optimal critical value of EGF in differential diagnosis of uterine myoma and healthy people was 288.5pg/ml.ROC curve area corresponding AUC value were 0.816 and 0.739 respectively.Serum MMP-9 and EGF levels in patients with submucosal myoma were higher than those with intramural myoma,the difference was statistically significant (P<0.05 ).The maximum diameter >5.0cm of the fibroids was less than or equal to ≤5.0cm of serum MMP-9 and EGF levels in patients with no statistically significant difference (P>0.05).Conclusion:Detections of serum EGF,MMP-9 levels are con-ducive to the differential diagnosis of uterine fibroids patients.
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