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首页> 外文期刊>European radiology >Methodological quality of diagnostic accuracy studies on non-invasive coronary CT angiography: Influence of QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) items on sensitivity and specificity
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Methodological quality of diagnostic accuracy studies on non-invasive coronary CT angiography: Influence of QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) items on sensitivity and specificity

机译：非侵入性冠状动脉CT血管造影诊断准确性研究的方法学质量：QUADAS（系统评价中包括的诊断准确性研究质量评估）项目对敏感性和特异性的影响

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摘要

Objectives: To evaluate the methodological quality of diagnostic accuracy studies on coronary computed tomography (CT) angiography using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies included in systematic reviews) tool. Methods: Each QUADAS item was individually defined to adapt it to the special requirements of studies on coronary CT angiography. Two independent investigators analysed 118 studies using 12 QUADAS items. Meta-regression and pooled analyses were performed to identify possible effects of methodological quality items on estimates of diagnostic accuracy. Results: The overall methodological quality of coronary CT studies was merely moderate. They fulfilled a median of 7.5 out of 12 items. Only 9 of the 118 studies fulfilled more than 75 % of possible QUADAS items. One QUADAS item ("Uninterpretable Results") showed a significant influence (P = 0.02) on estimates of diagnostic accuracy with "no fulfilment" increasing specificity from 86 to 90 %. Furthermore, pooled analysis revealed that each QUADAS item that is not fulfilled has the potential to change estimates of diagnostic accuracy. Conclusions: The methodological quality of studies investigating the diagnostic accuracy of non-invasive coronary CT is only moderate and was found to affect the sensitivity and specificity. An improvement is highly desirable because good methodology is crucial for adequately assessing imaging technologies. Key Points: ? Good methodological quality is a basic requirement in diagnostic accuracy studies. ? Most coronary CT angiography studies have only been of moderate design quality. ? Weak methodological quality will affect the sensitivity and specificity. ? No improvement in methodological quality was observed over time. ? Authors should consider the QUADAS checklist when undertaking accuracy studies.
机译：目的：使用QUAADAS（系统评价中包括的诊断准确性研究质量评估）工具评估冠状动脉计算机断层扫描（CT）血管造影诊断准确性研究的方法学质量。方法：每个QUADAS项目都经过单独定义，以适应冠状动脉CT血管造影研究的特殊要求。两名独立研究人员使用12个QUADAS项目分析了118项研究。进行了荟萃回归和汇总分析，以确定方法学质量项目对诊断准确性估计值的可能影响。结果：冠状动脉CT研究的总体方法学质量仅中等。他们完成了12个项目的中位数7.5。 118个研究中只有9个满足了超过75％的QUADAS项目要求。 QUADAS的一项内容（“无法解释的结果”）显示出对诊断准确性评估的显着影响（P = 0.02），“无成就”的特异性从86％提高到90％。此外，汇总分析显示，每个未实现的QUADAS项目都有可能更改诊断准确性的估计值。结论：研究非侵入性冠状动脉CT诊断准确性的研究方法学质量中等，被发现会影响敏感性和特异性。非常需要一种改进，因为好的方法对于充分评估成像技术至关重要。关键点： ？良好的方法学质量是诊断准确性研究的基本要求。 ？大多数冠状动脉CT血管造影研究仅具有中等设计质量。 ？方法学质量低下会影响敏感性和特异性。 ？随着时间的推移，未观察到方法学质量的改善。 ？在进行准确性研究时，作者应考虑QUADAS清单。

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