Thyroid hormone plays an important role in the growth,development and metabolism of cells and tissues,especially in the central nervous system.The monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter.Mutations and deletions of MCT8 gene can lead to Allan-Herndone-Dudley syndrome,which is characterized as neurodevelopmental disorder combined with thyroid function abnormalities.This paper reviews the different families of thyroid hormone transporters,with particular focus on the pathophysiology of MCT8 gene mutation.%甲状腺激素(TH)在细胞和组织的生长、发育、代谢中发挥了重要作用,尤其对神经系统发育作用更大.单羧酸转运蛋白8(MCT8)为T3特异性转运体,其基因突变可导致Allan-Herndone-Dudley综合征,主要临床特征为神经智力发育异常及甲状腺激素血清学异常.本文对甲状腺激素转运体的相关研究进行综述,并重点探讨MCT8功能缺失后重要器官的病理生理机制.
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