ABSTRACT:Objective To investigate the correlations of asthma control test(ACT)scores with sputum high-sensitivity C-reactive protein(hs-CRP)levels and airway reactivity in patients with nonallergic asthma.Methods The hs-CRP contents in sputum and pulmonary function were measured in 135 patients with nonallergic asthma(nonallergic asthma group)and 50 healthy sub-jects(control group).According to the ACT score,patients with nonallergic asthma were further divided into two groups:group A(ACT score≥20,n=58)and group B(ACT score<20,n=77). The airway reactivity was determined in both groups.The correlations of ACT scores with spu-tum hs-CRP contents and airway reactivity were analyzed by Pearson correlation analysis.Results Compared with control group,the hs-CRP contents in sputum increased and the FEV1,FEV1%, PEF and PEF% decreased in nonallergic asthma group(P <0.01).Compared with group A,the hs-CRP contents in sputum increased and the change in FEV1 decreased in group B(P <0.01 or P <0.05).The ACT scores were negatively correlated with the hs-CRP levels(r = -0.76,P <0.01),but positively correlated with the increased degree(%)and amount(mL)of FEV1 (r =0.85,P <0.05 and r =0.916,P <0.05,respectively ).Conclusion The ACT scores are closely correlated with sputum hs-CRP levels and airway reactivity in patients with nonallergic asthma. Therefore,ACT scores can be used as a simple measure to assess the development of nonallergic asthma.%目的：探讨哮喘控制测试（asthma control test，ACT）评分与非过敏性哮喘患者诱导痰液中超敏 C 反应蛋白（high-sensitivity C-reactive protein，hs-CRP）及气道反应性的相关性。方法选择135例非过敏性哮喘患者（非过敏性哮喘组）及50例同期健康体检者（对照组），检测2组痰液中 hs-CRP 含量及肺功能情况。再依据入院时ACT 评分将非过敏性哮喘患者分为2组，A 组58例（ACT 评分≥20），B 组77例（ACT 评分＜20），并检测其气道反应性。采用 Pearson 相关检验分析 ACT 评分与 hs-CRP 及气道反应性的相关性。结果非过敏性哮喘患者痰液中 hs-CRP 含量明显高于对照组，而肺功能各指标 FEV1、FEV1％、PEF 及 PEF％则显著低于对照组（均 P ＜0．01）。非过敏性哮喘 B 组患者痰液中 hs-CRP 水平较 A 组高（P ＜0．01），而反映气道反应性的 FEV1改变量均显著低于 A 组（P ＜0．05）。ACT 评分与 hs-CRP 含量呈负相关（r ＝－0．76，P ＜0．01），与 FEV1增加程度（％）和绝对值增加量（mL）呈正相关（r＝0．85，P ＜0．05；r ＝0．916，P ＜0．05）。结论ACT 评分与非过敏性哮喘患者升高的 hs-CRP 水平及气道反应性密切相关，正确使用该评分有助于简便、快捷地进行病情评估。
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