Objective To observe the effect of combined treatment with synchronized intermit-tent mandatory ventilation(SIMV)and pressure support(PS)on chronic obstructive pulmonary disease(COPD)and its clinical significance.Methods Ninety-two patients with COPD were given anti-infective therapy,anti-primary disease therapy,nutritional therapy and other conventional therapies.In addition,patients were randomly treated with SIMV alone(control group,n=45)or in combination with PS(observation group,n = 47).Changes in respiratory frequency,tidal vol-ume,minute ventilation,peak inspiratory pressure (PIP),partial pressure of carbon dioxide (PaCO2 ),partial pressure of oxygen(PaO2 ),oxygen saturation(SaO2 )and pH value were ob-served in both groups.Furthermore,mechanical ventilation time,time to liberation from mechani-cal ventilation,rate of successful liberation from mechanical ventilation and length of ICU stay were recorded in all patients.Results There were no significant differences in respiratory fre-quency,tidal volume,minute ventilation,PIP,PaCO2 ,PaO2 ,oxygen saturation SaO2 and pH value between the two groups(P >0.05).Mechanical ventilation time,length of ICU stay,time to liber-ation from mechanical ventilation and rate of successful liberation from mechanical ventilation were,respectively,(13±9)days,(15±10)days,(60±5)hours and 92.0% in observation group, and(21±11)days,(22 ± 8)days,(73 ± 8)hours and 73.8% in control group(P < 0.05).The differences were obvious between the two groups(P <0.05).Conclusion The combined treat-ment with SIMV and PS can shorten the time to liberation from mechanical ventilation,reduce ventilator dependency and promote recovery in patients with COPD.%目的：观察同步间歇指令通气（SIMV）联合压力支持（PS）对慢性阻塞性肺疾病（COPD）的临床疗效，探讨SIMV＋PS 的临床意义。方法将92例 COPD 患者按随机数字表法分为观察组（47例）和对照组（45例）。2组患者入院后均进行抗感染治疗、原发病治疗、营养治疗等常规疗法；对照组在此基础上行 SIMV，观察组行 SIMV＋PS。观察2组患者机械通气相关参数[呼吸频率、潮气量、每分钟通气量、吸气峰压（PIP）、动脉二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）、动脉血氧饱和度（SaO2）及 pH 值]的变化，记录2组患者的机械通气时间、脱机时间、脱机成功率及住 ICU 时间。结果2组患者呼吸频率、潮气量、每分钟通气量、PIP、PaCO2、PaO2、SaO2及 pH值比较差异均无统计学意义（均 P ＞0．05）。观察组机械通气时间、住 ICU 时间、脱机时间及脱机成功率分别为（13±9）d、（15±10）d、（60±5）h 及92．0％，对照组机械通气时间、住 ICU 时间、脱机时间及脱机成功率分别为（21±11）d、（22±8）d、（73±8）h 及73．8％，2组比较差异均有统计学意义（均 P ＜0．05）。结论SIMV＋PS 通气模式可加速脱机，减少 COPD 患者对呼吸机的依赖，利于患者早日康复。
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