Objective To assess efficacy and safety of duloxetine in the treatment of generalized anxiety disorder (GAD). Methods Hospitalized patients, diagnosed with the DSM — IV , a generalized anxiety disorder diagnosis standard, were randomly divided into duloxetine group( n = 38) and venlafax-ine group ( n =37) group, and treated for 8 weeks. Social function and safety were assessed using adverse drug reaction scale (TESS) at baseline, 2 weeks, 4 weeks and 8 weeks; efficacy was assessed using Hamilton Anxiety Scale (HAMA evaluate the clinical effect) at baseline and 8 weeks after treatment in Sheehan Disability Scale (SDS). Results The baseline characteristics of two groups showed no significant difference. After 2 weeks, 4 weeks, 8 weeks treatment, the efficient HAMA scores between the two groups, compared to baseline showed significant difference (P<0. 01), but there was no significant difference between the two groups (P>0. 05). After 8 weeks treatment the two groups showed lower score in SDS score with significant improvement (P<0. 01) compared to baseline. There was statistically significant difference (P<0. 05) between the two groups. The two groups did not show serious adverse drug reaction. Conclusions Duloxetine treatment in generalized anxiety disorder appear to be with fast effect, good curative effect, high safety, therefore help the recovery of social function.%目的 调查度洛西汀治疗广泛性焦虑障碍(GAD)的疗效及安全性.方法 将符合DSM-Ⅳ广泛性焦虑障碍诊断标准的住院患者随机分为度洛西汀组38例和文拉法辛组37例,进行为期8周的治疗观察；于基线时、治疗2,4,8周末评定汉密尔顿焦虑量表(HAMA)判断临床疗效；基线时及治疗8周末评定席汉残疾量表(SDS)评定社会功能恢复状况；药物不良反应量表(TESS)评价安全性.结果 两组治疗2,4,8周末在有效率、HAMA评分方面与基线时比较差异有统计学意义(P＜0.01),两组间比较差异无统计学意义(P＞0.05)；治疗8周末两组SDS评分均较基线时有明显改善,差异有统计学意义(P＜0.01),两组间比较有统计学意义(P＜0.05)；两组均未见严重药物不良反应.结论 度洛西汀治疗广泛性焦虑障碍起效快、疗效好、安全性高,同时对社会功能恢复起到积极作用.
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