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首页> 外文期刊>Journal of Behavioral and Brain Science >Efficacy and Safety of Vortioxetine and Duloxetine 60 mg Compared Placebo for the Treatment of Major Depressive Disorder: A Systematic Review and Meta-Analysis
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Efficacy and Safety of Vortioxetine and Duloxetine 60 mg Compared Placebo for the Treatment of Major Depressive Disorder: A Systematic Review and Meta-Analysis

机译：伏罗西汀和度洛西汀60 mg对比安慰剂治疗重大抑郁症的疗效和安全性：系统评价和荟萃分析

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Background: Major depressive disorder is a serious public health problem affecting the lives of millions in the worldwide and leading causes of disability and disease. This study aimed to evaluate the efficacy and safety of Vortioxetine and Duloxetine 60 mg compared to placebo for the treatment of major depressive disorder. Method: We searched the Cochrane library, Pub Med, CRD, Scopus, and Central Register of Controlled Trials to January 2015. We also searched ClinicalTrials.gov, International depressive disorder Conference and the Anxiety Disorders and Depression Conference. We identified that five randomized clinical trials were ultimately included in a Meta analysis. Data analysis was conducted by Standardized Mean Differences (SMD) for Montgomery-?sberg Depression Rating Scale (MADRS), and Odds Ratio (OR) for adverse events. The SMD and OR reported by 95% CI. Results: Results showed statistical significance in the MADRS for Vortioxetine (SMD = ﹣3.29; 95% CI ﹣4.47 to ﹣2.10; I2 = 99.3%) and for Duloxetine 60 mg (SMD = ﹣6.35; 95% CI ﹣8.84, ﹣3.87; I2 = 99.3%). Results showed that the Vortioxetine 2.5, 5, 10, 15, 20 mg and overall compared to placebo showed a significance for Nausea and no significance for diarrhea, dry mouth, dizziness, fatigue and headache. Also results of Duloxetine 60 mg showed a significant effect for dry mouth, dizziness, fatigue and nausea. Conclusion: It is necessary to do more studies so as to better assess and much more powerful than the evidence for the use of this drug in the treatment of depression.
机译：背景：严重的抑郁症是一个严重的公共卫生问题，影响着全球数百万人的生活，并且是导致残疾和疾病的主要原因。这项研究旨在评估与安慰剂相比，Vortioxetine和Duloxetine 60 mg治疗严重抑郁症的疗效和安全性。方法：至2015年1月，我们搜索了Cochrane图书馆，Pub Med，CRD，Scopus和对照试验中央登记册。我们还搜索了ClinicalTrials.gov，国际抑郁症会议以及焦虑症和抑郁症会议。我们确定了5项随机临床试验最终被纳入Meta分析。数据分析采用蒙哥马利抑郁量表（MADRS）的标准均值差（SMD）和不良事件的几率（OR）进行。 SMD和OR由95％CI报告。结果：结果显示，MADRS对伏替西汀（SMD = ﹣3.29; 95 ％CI ﹣4.47至﹣2.10; I2 = 99.3 ％）和度洛西汀60 mg（SMD = ﹣6.35; 95 ％CI ﹣8.84）有统计学意义。 ，﹣3.87; I2 = 99.3％。结果表明，与安慰剂相比，Vortioxetine 2.5、5、10、15、20 mg和总体剂量对恶心有显着意义，对腹泻，口干，头晕，疲劳和头痛无显着意义。杜洛西汀60 mg的结果也显示出对口干，头晕，疲劳和恶心的显着效果。结论：有必要做更多的研究，以更好地评估该药物，并比使用该药治疗抑郁症的证据更有效。

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