目的：研究身心康复锻炼对接受化疗的结肠癌患者发生癌因性疲乏的影响。方法将术后辅助化疗的72例结肠癌患者随机分成2组，对照组给予常规护理和运动宣教，观察组进行身心康复锻炼，包括步行锻炼、音乐放松、沙盘游戏，比较两组患者化疗前及化疗后癌因性疲乏的严重程度。结果（1）化疗前，两组均未出现重度疲乏；化疗第15天，观察组重度疲乏发生率为6%，对照组为11%（P=0.015）；化疗第29天，重度疲乏发生率观察组8%，对照组19%（P=0.006）。（2）化疗前，两组患者疲乏指数相似，差异无统计学意义；化疗第15天，疲乏指数观察组（4.82±0.66）分，对照组（7.11±0.87）分，两组比较差异有统计学意义（P=0.021）；化疗第29天疲乏指数观察组（4.95±1.03）分，对照组（8.64±1.22）分，两组比较差异有统计学意义（P=0.018）。结论采取运动锻炼、音乐放松、沙盘游戏身心方法，可以减轻化疗结肠癌患者癌因性疲乏。%Objective To investigate the effects of physical and psychological rehabilitation exercise on cancer related fatigue of colon cancer patients undergoing chemotherapy. Methods Seventy-two colon cancer patients treated with adjuvant chemotherapy were randomly divided into control group, in which patients received general nursing care and exercise guidance, and intervention group in which patients received a physical and psychological rehabilitation exercise, including walking, music therapy and sand-play. The cancer related fatigue of patients in both group was analyzed and compared. Results Patients in intervention group had lower incidence of severe cancer related fatigue (on day 15, 6% vs. 11%, P=0.015;on day 29, 8% vs. 19%, P=0.006) and lower level of fatigue intensity (BFI, on day 15, 4.82±0.66 vs. 7.11±0.87, P=0.021; on day 29, 4.95±1.03 vs. 8.64±1.22, P=0.018) than those in control group and the differences were statistically significant. Conclusion The physical and psychological rehabilitation exercise can effectively relieve cancer related fatigue of colon cancer patients undergoing chemotherapy.
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