Targeting therapy using the drugs selected by genetic detection is to block specific gene target and signaling pathway in tumor cells. The therapy can kill the tumor cells and does not affect normal cells, and has good curative effect and less side effects, so it is considered to be a treatment option of combined therapy for oral and maxillofacial-head and neck cancer. Targeting therapy combined by radiation therapy improves radiosensitivity. For advanced patients with tumor recurrence, or with distant metastasis, who can't tolerate with concurrent radiation and chemotherapy, targeted therapy can be used alone. Targeting therapy can decline risks of recurrence or worsening, and has the very big advantage in clinical application, and is becoming one of the indispensable important means of the combined therapy in the patients with oral and maxillofacial-head and neck cancer.%靶向治疗通过基因检测选择阻断个体肿瘤细胞信号通路及特定基因靶点的药物,打击肿瘤细胞而不殃及正常细胞,疗效好且毒副作用小,是口腔颌面-头颈部癌综合治疗的治疗选项.靶向治疗与放疗联用提高放射敏感性,对不能耐受同期放化疗的晚期、复发或伴有远处转移的患者也可单独应用.靶向治疗下降了头颈部癌复发或恶化风险,临床应用具有非常大的优势,正在成为综合治疗不可或缺的重要手段之一.
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