Taking drying powder of Artemisia argyi Lévl. et Vant. leaves as materials, single factor experiments about ultrasonic treatment time, solid-liquid ratio (mass-volume ratio), water bath temperature and extraction time which may affect on polysaccharide extraction rate were detected. And on this basis, four factors were optimized by L9(34) orthogonal experiment design. The results show that according to influence on extraction rate of polysaccharide, the order of four factors from high to low is extraction time, solid-liquid ratio, ultrasonic treatment time, water bath temperature. The optimal extraction condition is solid-liquid ratio 1:40, ultrasonic treatment time 20 min, water bath temperature 80 ℃, extraction time 2.0 h. Under the optimal condition, the extraction rate of polysaccharide from A. argyi leaves is the highest with a value of 12. 2%.
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