Objective To investigate the relationship between non-alcoholic fatty liver disease (NAFLD) and different histological types of primary bronchogenic carcinoma (lung cancer). Methods In-patients with pri-mary lung cancer,who had results of liver ultrasound check-up in Shanghai Pulmonary Hospital in 2009 and in 2013,were restrospectively enrolled in this study,and we tried to explore the relationship of NAFLD to what histo-logical types of lung cancer. Results Among 3664 patients with lung cancer recruted in the two years,807 pa-tients (22.0%) was found to have NAFLD,1379 (37.6%) was female,and 2189 (59.74%) was of adenocarcinoma;The percentage of female,adenocarcinoma,and NAFLD in 2607 patients with lung cancer presented in 2013 were significantly higher than those in 1057 patients met in 2009 (40.0% vs. 31.8%,67.8% vs. 40.2%,and 18.6% vs. 23.4,all P<0.001);In addition,the prevalence of NAFLD in patients with adenocarcinoma (545/2189,24.9 %) was significantly higher than that in squamous cell carcinoma (150/898,16.7%,P<0.01) or small cell lung cancer (16/86,18.6%,P<0.001) patients;NAFLD (OR 1.281,95% CI 1.025-1.600) and obesity(OR 1.391,95% CI 1.135-1.704) were independently positively,while male (OR 0.259,95% CI 0.208 -0.323) and smoking (OR 0.588,95%CI 0.486-0.712) were negatively correlated to adenocarcinoma of lung cancer by multiple regres-sion analysis. Conclusions Adenocarcinoma is becom-ing the most common histological type of lung cancer, and NAFLD is common in patients with pulmonary adenocarcinoma. Obesity and NAFLD might be associated with increased incidence of lung cancer of this type.%目的：探讨原发性支气管肺癌（肺癌）患者非酒精性脂肪性肝病（NAFLD）患病率及其与肺腺癌发生的关系。方法回顾性分析2009年和2013年上海市肺科医院收住的进行了腹部超声检查的肺癌患者的临床和病理学资料，经肺部肿瘤切除手术和（或）肺活检组织学检查确诊，使用美国GE公司生产的高档Vivid7彩色多普勒超声诊断仪行腹部超声检查。采用Logistic回归分析。结果在3664例肺癌患者中，807例合并NAFLD（22.0%），女性1379例（37.6%），腺癌2189例（59.74%）；与2009年度发现的1057例肺癌患者比，2013年度发现的2607例肺癌患者中女性（40.0%对31.8%，P<0.01）、肺腺癌（67.8%对40.2%，P<0.01）和NAFLD患病率（18.6%对23.4%，P<0.01）均显著增高；肺腺癌患者NAFLD患病率（545/2189，24.9%）显著高于肺鳞癌（150/898，16.7%，P<0.01）和小细胞肺癌（16/86，18.6%，P<0.01）；多元回归分析显示，肺癌患者中腺癌的比例与NAFLD （OR 1.281，95% CI 1.025～1.600）和肥胖（OR 1.391，95% CI 1.135～1.704）呈正相关，而与男性（OR 0.259，95%CI 0.208～0.323）和吸烟（OR 0.588，95%CI 0.486～0.712）呈负相关。结论腺癌已成为肺癌患者越来越重要的组织学类型，肺腺癌患者合并NAFLD常见，肥胖和NAFLD与肺腺癌的高发可能有关。
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