目的：评价清藓饮治疗口腔扁平苔藓（OLP）的临床疗效，并探索其调节 T 细胞介导的免疫应答机制。方法：25例OLP 患者服清藓饮，1剂／d，早、晚各1次，持续8周。空白对照组25例为健康志愿者，不服药。使用流式细胞术检测受试者外周血 CD4＋、CD8＋淋巴细胞计数和百分比及 CD4＋／CD8＋比值，观察评定“清藓饮”临床疗效。结果：患者经过8周的治疗后，显效18例，有效5例，无效2例，总有效率为92％。外周血中 CD4＋淋巴细胞计数及百分比上升（P ＜0．05），CD8＋淋巴细胞计数和百分比下降，CD4＋／CD8＋比值上升（P ＜0．05）。治疗后各项指标均向对照组方向变化。结论：清藓饮治疗口腔扁平苔藓有明显的临床疗效，在促进黏膜愈合、改善微循环、提高细胞免疫功能方面具有明显作用。%Objective:To evaluate of effects of Qingxianyin in the treatment of oral lichen planus(OLP),and to explore its regula-tion of T lymphocytes cellular immune mechanism.Methods:25 cases of OLP were treated by Qingxianyin for 8 weeks and 25 heathy subjects were served as the blank controls.Before and after treatment,peripheral blood CD4 +,CD8 + lymphocyte counts and percentages and CD4 +/CD8 + ratio were measured by flow cytometry.The clinical effects of Qingxinayin were evaluated.Results:After 8 weeks of treatment,significant effect,improvement and ineffecacy were observed in 1 8,5 and 2 cases respectively.The total effective ratio was 92.0%.The CD4 + lymphocyte counts and percentage increased(P <0.05),CD8 + counts and percentage de-creased(P <0.05),CD4 +/CD8 + ratio increased(P <0.05).After treatment the indexes changed towards those of the healthy con-trols.Conclusion:Qingxianyin is effective in the treatment of OLP by promoting mucosal healing,microcirculation and improving im-mune function.
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