Objective:To produce diatrizoate-gelatin microspheres with controllable diameters and to study their physical and chemical characters. Methods:Diatrizoate-gelatin microspheres with different diameters were prepared by emulsification and screening with sizer, the content of diatrizoate was measured by spectrophotometer, the development under X-ray was judged by X-ray photos, the expanding coefficient was measured by micrography. Results: The diatrizoate-gelatin microspheres with diameters around 30～1 000 tm could be screened out into groups with different diameters, and had good dispersibility. The content of diatrizoate was about (31±3)％. In animal and in vitro test proved that they were developable under X-ray. The coefficient of expanding was about 1.25～ 1.45 in normal saline. Conclusion: The diatrizoate-gelatin microspheres may be used as a new material for embolismic therapy.%目的：制备用于介入治疗的可显影、可控直径的固体栓塞材料--泛影葡胺明胶微球。方法：采用乳化聚合法制备微球，分样器过筛，分光光度计测定泛影葡胺含量，X线下判断其显影性，显微摄影测定其直径分布及膨胀系数，动物实验评估栓塞效果。结果：微球分散性良好，直径分布范围为30～1 000um，固相下可筛出不同直径的微球。微球中泛影葡胺的含量为(31±3)％。微球在生理盐水中的膨胀系数约为1．338。体外及动物实验证实其在X线下显影良好。结论：通过乳化聚合法制备的泛影葡胺-明胶微球分散性良好，直径可以控制，泛影葡胺含量高，X线下显影清晰，膨胀系数较大，是一种较为理想、具有广泛临床用途的新型固体栓塞材料。
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