Objective: GnRH antagonist (GnRH-ant) protocol is being widely accepted in IVF-ET because of the safety and convenience. However,the outcome of IVF-ET is still complicated in previous reports. The aim of this study was to compare the differences of IVF-ET outcome between GnRH-ant and GnRH agonist (GnRH-a) protocol.Methods: Sixty-four eligible undergoing IVF/ICSI patients were collected for this prospective randomized controlled trial:GnRH-ant group with 0. 25mg ganirelix(n = 32) and long GnRH-a group with 0. 05mg triptorelin(n = 32).Results: Compare with long GnRH-a group, GnRH-ant group showed lower total amount of gonadotropin required [( 1476. 61 ± 260. 11) vs. ( 1713. 28 ± 368. 46) IU, P ＜ 0. 01], shorter stimulation duration [(9. 59 ± 1. 29) vs. (10. 91 ± 1. 23) days, (P＜ 0. 001)] , and lower estradiol levels on HCG day [(8,646. 64 ± 3,714. 57)vs. (12,013. 84 ± 5,393. 67)pmol/L, (P＜0. 001)]. No differences were observed in two groups in average of top-quality embryo,implantation rate(30. 7% vs. 31. 5%) ,clinical pregnancy rate (48% vs. 48%)and live birth rate(41% vs. 44.4 %). Further more,the two groups showed a similar accumulative pregnancy (70% vs. 63%) and live birth rate (63. 3% vs. 60%) in the subsequent frozen embryo transfer(FET)cycles.Conclusions: GnRH-ant protocol might be an alternative choice for controlled ovarian hyperstimulation in IVF-ET.
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