目的：探讨E盒锌指结合蛋白2（ZEB2）和原癌基因C-myc（C-myc）在上皮性卵巢癌组织（EOC）中的表达情况，并分析其表达与EOC病理特征和预后的相关性。方法用免疫组化SP法检测191例EOC和13例正常卵巢组织中ZEB2和C-myc蛋白的表达，并分析ZEB2及C-myc蛋白的表达与肿瘤临床病理特征的相关性。结果 EOC和正常卵巢组织中ZEB2蛋白的阳性表达率分别为49.2%（94/191）和30.8%（4/13），差异有统计学意义（P=0.007）；C-myc蛋白的阳性表达率分别为53.9%（103/191）和15.4%（2/13），差异有统计学意义（P=0.001）。ZEB2蛋白的表达与EOC病理分型（P=0.003）、FIGO分期（P=0.028）、T分期（P=0.002）、淋巴结转移（P=0.04）有关。C-myc蛋白的表达与EOC中FIGO分期（P=0.035）、病理学分级（P=0.039）、T分期（P=0.002）有关。EOC组织中ZEB2与C-myc蛋白的表达有关联（R=0.358, P<0.001）。同时ZEB2及C-myc的共同表达在T分期和FIGO分期有关（P<0.001，P<0.008）。结论 ZEB2和C-myc有助于促进EOC的发展、浸润和转移，两者联合检测有望成为EOC的早期诊断指标。%Objective To investigate the expression patterns of ZEB2 and C-myc in epithelial ovarian cancer (EOC) and the associations between their expressions and the pathological features of EOC. Methods The expressions of ZEB2 and C-myc proteins were detected immunohistochemically in 191 cervical cancer tissues and 13 normal ovarian tissues. The relationship between ZEB2 and C-myc protein expressions and the clinicopathological features of EOC was evaluated. Results ZEB2 positive expression ratea in EOC tissues and normal ovarian tissues were 49.2% (94/191) and 30.8% (4/13), respectively (P=0.007), and C-myc positive expression rates in the two tissues were 53.9%(103/191) and 15.4%(2/13), respectively (P=0.001). A high expression of ZEB2 was positively correlated with the pathological type of the tumor (P=0.003), FIGO stage (P=0.028), T stage (P=0.002), and N stage (P=0.04), and a high expression of C-myc was positively correlated with FIGO stage (P=0.035), histological grade (P=0.039), and T stage (P=0.002). C-myc and ZEB2 expressions were positively correlated in EOC (P<0.001), and their co-expression in EOC was significantly correlated with T stage (R=0.358, P<0.001) and FIGO stage (P=0.008). Conclusion ZEB2 and C-myc can promote the progression, invasion and metastasis of EOC, and their combined detection may assist in early diagnosis of EOC.
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