目的 研究精神分裂症(SC H)合并抑郁症状患者的血清甲状腺激素水平变化规律.方法 选取伴抑郁症状的SC H患者59例(A组),不伴抑郁症状SC H患者55例(B组),单纯抑郁症患者52例(C组)与同期健康志愿者60例(D组).检测和比较各组血清甲状腺激素水平[包括甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、三碘甲状腺原氨酸(TT3)及甲状腺素(TT4)].结果 治疗前A、C组的TT4、TSH、FT3水平与D组差异有统计学意义(P<0.05),A组与C组间比较差异无统计学意义(P>0.05),治疗后两组均较治疗前显著改善,差异有统计学意义(P<0.05);治疗前B组的FT3、TT4水平与D组差异有统计学意义(P<0.05),治疗后较治疗前显著改善,差异有统计学意义(P<0.05).有效组与无效组治疗前及治疗后TSH、TT3、TT4、FT4水平差异无统计学意义(P>0.05),而有效组治疗前、后FT3水平均显著高于无效组(P<0.05);A、B、C 3组的治疗有效率分别为71.19%(42/59)、74.55%(41/55)、71.15%(37/52),3组间比较差异无统计学意义(P>0.05).结论 SCH伴抑郁症状患者出现一定的血清甲状腺激素水平异常,甲状腺激素水平改变,尤其是FT3水平降低可能与抑郁症状的发生及临床转归有关.%Objective To study the change rule of serum thyroid hormone levels in the patients with schizophrenia (SCH) com-plicating depressive symptoms .Methods Fifty-nine cases of SCH complicating depressive symptoms (group A) ,55 cases of SCH patients without complicating depressive symptoms (group B) ,52 cases of simple depression(group C) and contemporaneous 60 healthy volunteers(group D) were selected .Serum thyroid hormone levels (including TSH ,FT3 ,FT4 ,TT3 and TT4) in various groups were detected and compared .Results The levels of TSH ,FT3 and TT4 before treatment had statistical differences between the group A and C with the group D(P<0 .05) ,but which had no statistical difference between the group A and C (P>0 .05) ,the two groups after treatment were significantly improved compared with before treatment ,the difference was statistically significant (P<0 .05);the levels of FT3 and TT4 before treatment had statistical difference between the group B and D (P<0 .05) ,after treat-ment was significantly improved compared with before treatment ,the difference was statistically significant (P<0 .05) .The levels of TSH ,TT3 ,TT4 and FT4 before and after treatment had no statistical difference between the effective group and ineffective group (P>0 .05) ,while the FT3 level before and after treatment in the effective group was significantly higher than that in the ineffective group(P<0 .05);the treatment effective rates in the group A ,B and C were 71 .19% (42/59) ,74 .55% (41/55) and 71 .15%(37/52) ,there was no statistically significant difference among the three groups (P>0 .05) .Conclusion SCH patients complicating depressive symptoms have a certain serum thyroid hormone abnormalities ,the thyroid hormone level changes ,especially the FT3 de-crease ,may be related to the occurrence of depressive symptoms and clinical outcome .
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