目的：了解新疆不同民族男性人群血清糖缺失性转铁蛋白（CDT）水平，评估CDT鉴别长期慢性酗酒男性人群的作用。方法采用问卷调查法确定131名正常男性（正常对照组，其中汉族53名、维吾尔族46名、哈萨克族32名）和96例长期慢性酗酒男性（长期酗酒组，其中汉族45例、维吾尔族31例、哈萨克族20例）为研究对象，采用毛细管电泳法检测血清CDT水平，然后通过P-P正态性检验确定CDT的参考区间。采用受试者工作特征（ROC）曲线确定CDT识别长期慢性酗酒者的临界值。结果长期酗酒组CDT水平为3.530%±0.833%，明显高于正常对照组（0.716%±0.341%，P<0.001）。2个组的组内不同民族之间CDT水平差异均无统计学意义（P>0.05）。初步确定新疆地区正常男性人群的血清CDT参考区间为<1.28%。ROC曲线分析显示CDT识别长期慢性酗酒者的临界值为1.25%，敏感性为81.3%，特异性为92.3%，曲线下面积为0.948。结论新疆地区少数民族血清CDT可以应用同一个参考区间。采用CDT识别长期慢性酗酒者具有较好的敏感性和特异性，可完全满足临床需要。%Objective To study serum carbohydrate deficient transferrin(CDT)level of males with different nationalities in Xinjiang,and to assess the role of CDT in identifying alcohol abuse among males. Methods A questionnaire survey was conducted,and 131 healthy subjects (healthy control group,including 53 cases of Han, 46 cases of Uygur and 32 cases of Kazak) and 96 subjects with alcohol abuse (alcohol abuse group,including 45 cases of Han,31 cases of Uygur and 20 cases of Kazak)were enrolled. Serum CDT level was determined by capillary electrophoresis. The reference interval and cut-off value were determined by P-P normality test and receiver operating characteristic(ROC) curve,respectively. Results The CDT level of alcohol abuse group was 3.530%±0.833%, which was higher than that of healthy control group (0.716%±0.341%,P<0.001). There was no statistical significance for different nationalities in 2 groups(P>0.05). The reference interval for serum CDT level in healthy control group was <1.28%. According to ROC curve,the cut-off value for alcohol abuse group was 1.25%, the sensitivity was 81.3%,and the specificity was 92.3%. The area under ROC curve was 0.948. Conclusions The reference interval of serum CDT level in healthy subjects with different nationalities in Xinjiang could use the same level. The determination of CDT has good sensitivity and specificity for identifying alcohol abuse,which meets clinical needs.
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