Objective:To explore the effect of combined therapy of clopidogrel and aspirin in short-term plus aspirin in patients with recurrent cerebral infarction. Methods:82 patients with recurrent cerebral infarction in our hospital from Oct 2012 to Oct 2014 were randomly divided into clopidogrel plus aspirin therapy group (research group,n=41) and aspirin group (control group,n=41)and the recurrent cerebral infarction rates were compared between the two groups at in-hospital 14 days and out-hospital 6 months. Results: The total acute cerebral infarction rate in research group was significantly lower than that in the control group (7.3% vs 22.0%,P<0.05). Conclusion:It should as far as possible take short-term clopidogrel and aspirin treatment for patients with recurrent cerebral infarction without contraindication to the consent of the cases , in order to reduce the incidence of recurrent acute cerebral infarction.%目的：探讨反复发作性脑梗死患者短期加用氯吡格雷联合阿司匹林抗血小板聚集治疗的有效性。方法：将2012年10月至2014年10月我院神经内科及综合内科收治的反复发作性脑梗死患者82例随机分成氯吡格雷＋阿司匹林治疗组（研究组，n＝41）和阿司匹林治疗组（对照组，n＝41），比较两组住院14日及出院6个月内急性脑梗死的总再次发生率。结果：研究组急性脑梗死总再次发生率明显低于对照组（7．3％ vs 22．0％，P＜0．05）。结论：反复发作性脑梗死患者若无禁忌症及患者同意，应尽早行短期应用氯吡格雷联合阿司匹林治疗，以降低急性脑梗死的再次发生率。
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