目的：探究原发性痛经患者外周血细胞因子和PGF2α的变化及临床意义。方法：选取2011年11月-2013年11月来本科就诊的50例原发性痛经患者作为观察组，选取同期来本院体检的50例健康月经期女性作为对照组。利用酶联免疫吸实验（ELISA）法对两组女性的经期外周血细胞因子和PGF2α的变化情况进行测定，比较两组经前、经中IL-10、IFN-r、PGF2α等指标的变化情况。结果：观察组经前1周内、经中IL-4、IL-5水平无明显变化（P>0.05），而经中IL-10、IFN-r、PGF2α水平高于经前（P<0.05）。对照组经前1周内、经中IL-4、IL-5、 IL-10、IFN-r水平均无明显变化（P>0.05），但经中PGF2α水平高于经前（P<0.05）。观察组经中的IL-5、IL-10、IFN-r、PGF2α水平均明显高于对照组经中水平（P<0.05）。结论：原发性痛经发病机制与PGF2α分泌量、外周血细胞因子有关，原发性痛经患者体内的外周血细胞因子和PGF2α水平会出现异常变化，且PGF2α分泌与细胞免疫因子具有一定关系。%Objective: To explore the primary dysmenorrhea in patients with peripheral blood cell factor and PGF2 alpha and its clinical significance.Method: 50 cases of primary dysmenorrhea from November 2011 to November 2013 in our department were selected as the observation group, 50 cases of healthy female menstrual period over the same period in our hospital the examination were selected as the control group. Used enzyme-linked immunosorbent test (ELISA) changes of two groups of female menstruation method of peripheral blood cytokines and PGF2 alpha were measured, and IL-10, through IFN-r, PGF2 alpha change between the two groups were compared.Result: The observation group was within 1 weeks before, by IL-4, no significant change of IL-5 (P> 0.05), while the IL-10, IFN-r, PGF2 in the alpha level than the former (P<0.05). Before 1 weeks the IL-4, IL-5, IL-10, IFN-r of the control group had no significant change (P> 0.05), but the PGF2 alpha level was higher than before (P<0.05). The observation group’s IL-5, IL-10,IFN-r, PGF2 levels were significantly higher than those in control group(P<0.05).Conclusion:Primary dysmenorrhea and the pathogenesis of PGF2 alpha secretion, peripheral blood cell factors, cytokines in peripheral blood in patients with primary dysmenorrhea in vivo and PGF2 levels will appear abnormal changes in PGF2 secretion, and has a certain relationship with cell immune factor.
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