Objective:To compare dexmedetomidine’s and midazolam’s sedation and analgesia effects on patients who stayed in intensive care unit,and evaluate dexmedetomidine’s functions. Method:Chosed 50 cases who required sedation and analgesia,divide them into group A and group B according to their hospital admission times. Group A was dexmedetomidine group and group B was midazolam group. To analyze effects and side-effect of these two kinds of medicines. Result:Both group A and group were satisfied with these two medicines’sedation and analgesia effects. With regard to awake time,group A was better than group B,but in terms of the duration of ventilatory support and VAS marks,there was no difference between these two groups. With regard to frequency of hypopnea,hypotension,bradycardia,and anterograde amnesia,group A was better than group B(P<0.05). Conclusion:Dexmedetomidine has good sedation and analgesia effects on those patients who stayed in intensive care unit,the happening frequency of hypopnea,hypotension,bradycardia,and anterograde amnesia is lower. It is worthy of promotion in intensive care unit.% 目的：比较右美托咪啶和咪达唑仑在重症监护病房的患者中的镇静、镇痛效果，评价右美托咪啶的作用。方法：选取本院50例ICU需要镇静镇痛的患者，按收治的先后顺序将他们分成A、B两组，A组应用右美托咪啶，B组应用咪达唑仑，对两组药物的作用效果及副作用进行分析。结果：A、B两组的镇静镇痛效果的满意度都很高。A组唤醒时间短于B组，但两组机械通气时间和VAS评分比较差异无统计学意义。A组呼吸减弱、低血压、心动过缓、顺行性遗忘等现象的出现频率均优于B组，比较差异有统计学意义（P<0.05）。结论：右美托咪定对重症监护病房的患者的镇静镇痛效果好，低血压，呼吸过缓，心动过缓，顺行性遗忘等副作用的发生概率小，可广泛应用于重症监护病房。
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