目的:探讨中药方剂联合西药口服治疗慢性牙周炎的效果及对牙龈组织中细胞间黏附分子-1 (ICAM-1) 表达的影响.方法:选择2017年1月-2018年1月东莞市石碣医院口腔门诊收治的慢性牙周炎患者80例为研究对象, 按照随机数字表法分成观察A组和观察B组, 每组40例;另选择同期性别年龄相匹配的健康牙龈患者40例为对照组.观察B组采用常规牙周基础及西药口服治疗, 观察A组在此基础上, 根据患者的中医辨证分型自拟方剂辅助治疗, 观察比较两组慢性牙周炎患者的临床疗效, 采用免疫组化Elivsion法检测比较三组患者牙龈组织中ICAM-1表达水平.结果:观察A组的治疗总有效率 (92.50％) 明显高于观察B组 (72.50％), 差异有统计学意义 (P＜0.05) .观察A组和观察B组患者的牙龈组织中ICAM-1表达均显著高于对照组 (P＜0.05), 而观察A组和观察B组患者治疗前牙龈组织中ICAM-1阳性表达率比较, 差异无统计学意义 (P＞0.05) .治疗后, 观察A组患者牙龈组织中ICAM-1阳性表达率明显较治疗前下降 (P＜0.05), 而观察B组患者牙龈组织中ICAM-1阳性表达率变化不明显, 观察A组牙龈组织中ICAM-1阳性表达率明显低于观察B组 (P＜0.05) .结论:中药方剂联合西药口服治疗能有效提高慢性牙周炎的治疗效果;慢性牙周炎患者的牙龈组织中存在ICAM-1过表达, 中药方剂能抑制ICAM-1的表达, 进而减少炎症反应和组织破坏.%Objective:To explore the curative effect of traditional Chinese medicine prescription combined with western medicine on chronic periodontitis and the expression of ICAM-1 in gingival tissue.Method:A total of 80 patients with chronic periodontitis of Shijie Hospital of Dongguan City from January 2017 to January 2018 were selected as study objects, and they were randomly divided into observation group A and observation group B, 40 cases in each group.Another 40 healthy gingival patients with matching gender and age at the same time were selected as the control group.Observation group B was treated with conventional periodontal and oral administration of western medicine.On the basis of observation group B, observation group A was treated with traditional Chinese medicine prescription.The clinical efficacy of two groups was observed and the ICAM-1 expression level in the gingival tissue of three groups were detected by Elivsion method.Result:The treatment efficiency of the observation group A (92.50％) was significantly higher than that of the observation group B (72.50％), there was statistical significance (P＜0.05).ICAM-1 expression in the gingival tissues of both observation group A and B were significantly higher than that of the control group (P＜0.05), while the positive expression rate of ICAM-1 in the gingival tissues of observation group A and B before treatment showed no significant difference (P＞0.05).After treatment, the positive expression of ICAM-1 rate of the observation group A reduced significantly than that of before treatment (P＜0.05), while the positive expression of ICAM-1 rate of the observation group B changed a little, and the positive expression rate of ICAM-1 of the observation group A was significantly lower than that of the observation group B (P＜0.05).Conclusion:The combination of traditional Chinese medicine prescription and western medicine periodontal can effectively improve the therapeutic effect of chronic periodontitis.ICAM-1 overexpression exists in gingival tissue of patients with chronic periodontitis.Traditional Chinese medicine prescription can inhibit the expression of ICAM-1 and thus reduce the inflammatory reaction and tissue destruction.
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