Objective:To study application effects of contrast-enhanced ultrasound ( CEUS) in the masses biopsies of the sol-id organ. Methods:A total of 98 patients with masses in the solid organs (80 cases with liver masses, 10 cases with breast masses, 8 cases with kidney masses) were recruited and randomized into 2 groups with 49 cases in each group. For CEUS group, the puncture site was determined upon focal imaging. For control group, a regular ultrasound and Doppler ultrasound were used for locating the puncture site. The puncture success rates of the two groups were compared. Results: A total 113 out of 115 cases were successfully punctured in CEUS group and the other 2 failed. Compare to CEUS group, 108 out of 119 were successfully punctured and the other 11 failed in control group. The difference of the success rate between CEUS and control group was statistically significant (P<0. 05). Conclusions:The puncture success rate of CEUS before the masses biopsies of the solid organ is higher than the regular ultrasound and Doppler ultrasound.%目的：：观察超声造影在患者实质性器官肿物活检前的应用效果。方法：将98例实质性器官肿物患者(含肝脏肿物80例，乳腺肿物10例，肾脏肿物8例)分为观察组和对照组，每组各49例。两组患者行超声引导下肿物活检。观察组患者在活检前进行超声造影检查，根据病灶造影表现，决定穿刺部位；对照组患者活检前进行常规超声及多普勒检查结果定位穿刺。比较两组患者的穿刺成功率。结果：观察组患者共穿刺115条，成功113条，破碎2条；对照组患者共穿刺119条，成功108条，破碎11条，观察组患者的穿刺成功率优于对照组，具有统计学差异(P<0.05)。结论：超声造影在患者实质性器官肿物活检前应用的穿剌成功率优于常规超声和多普勒。
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