AIM To evaluate the diagnostic value of the intestinal metaplasia of stomach by ordinary en-doscopy, Fuji intelligent chromo endoscopy (FICE)endoscopy, and FICE staining technique combined with acetic acid. Methods From December 2012 to December 2014, the suspected intestinal metaplasia (IM) of stomach found by ordinary endoscopy was divided into 3 groups with 128 cases in each. The patients were checked by ordinary endoscopy, FICE endoscopy, and FICE staining endoscopy combined with acetic acid. The diagnostic power for intestinal metaplasia of the stomach by different methods was compared. Results FICE endoscopy, FICE staining endoscopy combined with acetic acid had higher sensitivity and accuracy in the diagnosis of IM than ordinary endoscopy, the difference was statistically significant (P<0.05). Compared with FICE endoscopy, FICE staining endoscopy combined with acetic acid had higher accuracy, sensitivity, negative predictive value, the difference was statistically significant (P<0.05), but the specificity, the positive predictive value of the difference was not statistically significant (P>0.05). Conclusion FICE endoscopy, FICE staining endoscopy combined with acetic acid was better than acetic acid staining endoscopy for the di-agnosis of intestinal metaplasia.%目的：比较普通内镜、智能分光染色(FICE)内镜、FICE内镜结合乙酸染色在胃黏膜肠上皮化生检出中的诊断价值。方法从2012年12月至2014年12月，将我院普通内镜发现的可疑肠上皮化生病变患者分为3组各128例。分别采用普通内镜、FICE内镜、乙酸染色结合FICE内镜进行观察。比较不同方法诊断肠上皮化生的结果。结果 FICE内镜、FICE结合醋酸染色内镜诊断IM的敏感度、特异度优于普通内镜，差异有统计学意义(P<0.05)。 FICE内镜与FICE结合醋酸染色内镜组间比较提示两者敏感度、总符合率、阴性预测值差异有统计学意义(P<0.05)，但特异度、阳性预测值差异无统计学意义(P>0.05)。结论 FICE内镜、乙酸染色结合FICE内镜对肠上皮化生的诊断均优于普通内镜，乙酸联合FICE内镜较普通FICE内镜更能发现肠上皮化生病灶，减少漏诊，具有更高临床诊断价值。
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