Objective To investigate the effect of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in the treatment of skin cancer. Method A total of 80 cases of skin cancer patients who received either ALA-PDT+surgery (n=43) or surgery alone (n=37) were included in the analysis, and the clinical effect and recurrence in the two groups were compared. Result All the 43 patients in combined therapy group had completed ALA-PDT treatment, in which 38 cases (88.37%) had response, and 5 (11.63%) were cured;the lesion area were similar between the two groups before treatment (P>0.05), while the surgical wound area was less in in combined therapy group than that of single surgery group (P<0.05), with higher satisfaction rate for appearance observed in the combined therapy group (P<0.05);the recurrence rate was 9.30%and 18.60%in combined therapy group in 12 and 24 months after surgery, and was 16.22%and 35.14%in sur-gery group, respectively, though the difference was not statistically significant (P>0.05); the disease-free survival time was 22 months and 20 months in combined therapy group and single surgery group, respectively, which was of no statisti-cally significant difference (P>0.05). Conclusion ALA-PDT combined with surgery may reduce the area of the surgical wound in the treatment of skin cancer, facilitating the recovery of appearance after surgery, though the long-term effect should be further determined in extended follow-up.%目的 探讨5-氨基酮戊酸光动力疗法(ALA-PDT)治疗皮肤癌的效果.方法 选取80例皮肤癌患者,根据患者是否采用ALA-PDT治疗分为联合组(ALA-PDT+手术治疗)43例、单纯手术组(单纯手术治疗)37例,对比两组疗效及复发情况.结果 联合组43例患者均完成了ALA-PDT治疗,其中治疗显效38例(88.37%)、有效5例(11.63%);联合组的术前病灶面积与单纯手术组比较,差异无统计学意义(P﹥0.05);联合组的手术创面面积小于单纯手术组,外观满意度高于单纯手术组,差异均有统计学意义(P﹤0.05);联合组术后12个月的复发率为9.30%,24个月的复发率为18.60%,单纯手术组分别为16.22%、35.14%,两组比较差异无统计学意义(P﹥0.05);联合组术后疾病无进展生存时间为22个月,单纯手术组为20个月,两组比较差异无统计学意义(P﹥0.05).结论 ALA-PDT结合手术治疗皮肤癌有利于减小手术创面面积,对患者术后创面外观恢复有利,但是对皮肤癌患者的远期疗效尚需进一步延长随访时间进行观察.
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