Objective The aim of this study is to investigate the expression of CA19-9in various people and situations a-long with other item of multiple tumor marker protein chip. Methods 25 ,076 cases detected with multiple tumor markers chip were collected. The elevation of CA19-9 and its combination with other item of multiple tumor marker protein chip were analyzed in malignant tumors and other people. Results Elevated CA19-9 in patients with malignant tumors was significantly higher than in benign lesions and healthy people. The positive rate was the highest in pancreatic cancer( 62. 04% ), followed by liver cancer ( 44. 25% ),gastric cancer( 26. 40% ) and colorectal cancer( 26. 32% ). The pattern of CA19-9 combined with CA242 or CEA was most observed in colorectal cancer( 90.00% , 86. 45% ), and CA19-9 + CA125 most observed in lung cancer( 71. 66% ). The CA19-9 + CA242 + CA125 combined pattern was most seen in pancreatic cancer( 54. 91% ); CA19-9 + CA242 + CEA most seen in colorectal cancel 81. 61% );CA19-9 + AFP + CA125 most seen in hepatocellular carcinoma ( 32. 14% );CA19-9 + CEA + CA125 most seen in lung cancer ( 55. 56% ). Conclusion CA19-9 generally expressed in malignant tumors,but is not specific for malignant tumors. CA19-9 single increase in digestive carcinoma has a high diagnostic value, especially most seen in pancreatic cancer,and CA19-9 combined with CA242、CEA or CA125 was significant to improve the positive rate of each cancer,and to re duce the rate of misdiagnosis.%目的 探讨多肿瘤标志物蛋白芯片中糖链抗原CA19-9水平升高的临床诊断意义.方法 收集可供分析的25 076例多肿瘤蛋白芯片检测结果,分析CA19-9水平在各人群、各肿瘤组织中升高情况.结果 恶性肿瘤患者CA19-9水平升高发生率明显高于良性病变患者及正常体检者,且胰腺癌发生率最高(62.04%),其次为肝癌(44.25%)、胃癌(26.40%)、结直肠癌(26.32%);CA19-9伴随升高的指标以CA242最为常见,其次为CEA、CA125;CA19-9/CA242、CA19-9/CEA伴随升高最常见于结直肠癌(90.00%,86.45%);CA19-9/CA125伴随升高最常见于肺癌(71.66%).CA19-9+CA242+CA125联合升高最常见于胰腺癌(54.91%);CA19-9+CA242+CEA联合升高最常见于结直肠癌(81.61%);CA19-9+AFP+CA125联合升高最常见于肝癌(32.14%);CA19-9+CEA+CA125联合升高最常见于肺癌(55.56%).结论 CA19-9在恶性肿瘤中广泛表达,但并非恶性肿瘤的特异性指标.CA19-9单项指标升高对消化系统肿瘤具有较高的诊断价值,尤其对胰腺癌,而CA19-9伴随CA125、CA19-9、CA242水平升高,有助于提高各肿瘤诊断阳性率,降低误诊率.
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