Objective:Assess Procalcitonin dynamic change,High-sensitivity C-reactive crotein Prealbumin in patients with COPD before clinical significance,provide reference for clinical diagnosis and treatment. Methods:Will our respiratory medicine in August 2014 - December 2015 ended 80 COPD patients in hospital into the study as observation group,80 cases of patients with COPD were measured and recorded in the acute phase and stability of calcitonin original,allergic C - reactive protein levels and albumin level before,will be August 2014 - December 2015 80 cases of healthy persons as control group and test results were compared. Rsult:The acute phase of PCT and hs - highest CRP levels(P﹤0. 05);Acute phase albumin levels significantly below the period before the albumin levels,difference has statistical significance(P﹤0. 05). Conclusion:Procalcitonin,High-sensitivity C-reactive crotein and Prealbumin levels and correlated with the severity of the COPD dis-ease,its dynamic changes can evaluate the prognosis of patients with COPD.%目的：探讨动态评估降钙素原（ PCT）、超敏C-反应蛋白（ hs-CRP）及前白蛋白（ PA）在慢性阻塞性肺疾病（ COPD）患者的临床意义，为临床诊疗提供参考。方法：将2014年8月—2015年12月收住院的80例COPD患者作为观察组，检测并记录80例COPD患者在急性期及稳定期的PCT、hs-CRP及PA水平；将2014年8月—2015年12月间的80例健康体检者作为对照组，并将两组检测结果进行对比。结果：COPD急性期PCT及hs-CRP含量最高（ P﹤0.05）；急性期PA水平显著低于稳定期，差异具有统计学意义（ P﹤0.05）。结论：PCT、hs-CRP及PA水平和COPD疾病的严重程度有相关性，其动态变化可评估COPD患者的预后。
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