Objective:When the elderly patients with rectual cancer or conlon cancer were treated by FOLFOX4 chemo-therapy,to explore whether peripherally Inserted Central Catheters( PICC)is better than past infusion methods. Methods:All 163 patients cured by FOLFOX4 were divided into 3 groups with different infusion methods:PICC group,central venous cathe-terization( CVC)group,superficial vein detaining needle group. To observe the incidence of phlebitis,drug extravasation and pipes blockage after cured by FOLFOX4 for 2~4 weeks. Questionnaire survey to all patients whether quality of life was in-funced by the infusion method. Results:To compare other groups,the rates of phlebitis and drug extravasation were descented significantly(P﹤0. 05). All patients could accept the infusion method. Conclution:PICC was safer and accepted by patiants, could be extended in clinic.%目的：针对结直肠癌老年患者采用FOLFOX4方案全身化疗，探讨外周中心静脉置管术（ PICC）较以往输液方式有无优势。方法：将163例老年结直肠癌患者随机分为PICC组、经锁骨下中心静脉置管术（ CVC）组、浅静脉留置针组，采用FOLFOX4全身化疗2~4周期，观察静脉炎、药物外渗、导管堵塞发生率以及问卷调查输液方式对生活质量的影响。结果：与其他组比较，PICC组可明显减低静脉炎、药品外渗发生率，差异有统计学意义（ P﹤0.05）。问卷调查显示，所有患者可接受此种输液方式。结论：PICC在老年结直肠患者FOLFOX4化疗中，安全性高，能为患者所接受。
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