对比热浪过程前后健康小鼠与ApoE-/-小鼠ET-1、NO及体温的变化,探讨热浪对ApoE-/-小鼠体温的影响机制.选取南京2001-2010年间一次实际热浪天气过程,运用气象环境模拟箱模拟,将健康小鼠与ApoE-/-小鼠分为对照组和热浪组(n=6),测定其热浪前后血管内皮素-1(ET-1)和一氧化氮(NO)的含量以及体温的变化.结果显示热浪刺激后,ApoE-/-小鼠的体温、NO含量上升明显,体重、ET-1水平及NO/ET-1比值变化不大,体温变化、NO含量及NO/ET-1比值相对于健康小鼠差异显著.研究结果ApoE-/-小鼠在热浪过程中更易受到热浪的影响,是冠心病患者更易受高温热浪影响的可能机理之一.%The effects of heat wave on ApoE-/-mice by comparing the variations of ET-1,NO and body temperature between C57BL/6/J mice and ApoE-/-mice are observed.A heat wave weather process during 2001 to 2010 was simulated by climate simulator.The content of ET-1 and NO and the body temperature of mice,which were divided into 2 groups (n =6):control group and heat-wave group,were detected during the heat wave.The results indicated that,when suffering the heat wave,the NO level and the body temperature were rising obviously,but the weight,the ET-1 content and the ratio between NO and ET-1 were not changing much.At the meantime,the variations of NO,the ratio and the body temperature of ApoE-/-mice were more significant than C57BL/6/J mice.ApoE-/-mice were more vulnerable when suffering the heat wave,which might be one of the mechanisms of the phenomenon that coronary artery disease patients are more vulnerable to heat wave weather.
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