Objective:To study the correlation between the maternal subclinical hypothyrodism and obstetric outcome.Methods:125 maternal subclinical hypothyrodism accepted the thyroid function examination were saw as observation group, and the group were given the treatment of sodiumlevothyroxine (L-T4) in early stage.At the same time, and 118 normal pregnancy women in the same period were selected as control group.The outcome of pregnancy in two groups were analyzed.Results: The incidence rate of gestational diabetes, premature rupture of membranes, anemia, postpartum hemorrhage, fetal distress , fetal growth restriction of observation group were significantly higher than the control group (P<0.05).However, the incidence rate of hypertension, intrahepatic cholestasis, abortion, hypoproteinemia, low birth weight , neonatal asphyxia and fetal malformation between the two groups had no significant differences (P>0.05).Conclusion:Maternal subclinical hypothyrodism can cause adverse pregnancy outcomes, therefore, the patients should be accepted regular treatment which could reduce the adverse pregnancy outcomes to improve the thyroid function.%目的:探讨妊娠合并亚临床甲状腺功能减退症 (亚临床甲减) 对妊娠和胎儿的影响.方法:观察组选取亚临床甲减孕妇125例,早期给予左甲状腺素 (LT-4) 干预治疗,对照组随机选取同期就诊的正常妊娠孕妇118例,对比分析两组孕妇妊娠和胎儿情况.结果:观察组孕妇妊娠期糖尿病、胎膜早破、贫血、产后出血及胎儿宫内窘迫和胎儿宫内生长受限发生率显著高于对照组 (P<0.05).而两组孕妇妊娠期高血压、肝内胆汁淤积、流产、低蛋白血症及低出生体重、新生儿窒息和胎儿畸形的发生率无统计学差异 (P>0.05).结论:妊娠合并亚临床甲减对妊娠结局造成严重不良影响,应及时规范给予LT-4治疗改善甲状腺功能,进而减少不良妊娠结果.
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